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FGF2 — HOXB9
Text-mined interactions from Literome
Curran et al., Dev Biol 2000
:
Inhibition of
FGF signaling does not
block posterior neural gene expression (
HoxB9 ) or activation of MAPK ; however, inhibition of FGF signaling does cause a statistically significant decrease in the level of activated MAPK
Naora et al., Proc Natl Acad Sci U S A 2001
(Ovarian Neoplasms) :
Furthermore,
HOXB7 overexpression
increased intracellular accumulation and secretion of basic
fibroblast growth factor , a potent angiogenic and mitogenic factor ... Furthermore,
HOXB7 overexpression
increased intracellular accumulation and secretion of
basic fibroblast growth factor , a potent angiogenic and mitogenic factor
Shiotsugu et al., Development 2004
:
Overexpression of a constitutively active RARalpha2 rescues the
effects of
FGF blockade on the expression of XCAD3 and
HOXB9
Hayashida et al., Proc Natl Acad Sci U S A 2010
(Breast Neoplasms...) :
HOXB9 induces the expression of several angiogenic factors ( VEGF,
bFGF , IL-8, and ANGPTL-2 ), as well as ErbB ( amphiregulin, epiregulin, and neuregulins ) and TGF-ss, which activate their respective pathways, leading to increased cell motility and acquisition of mesenchymal phenotypes