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IFNG — NOS3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: NOS3 → IFNG (increases, IFNG Activity)
  Evidence: These findings reveal the importance of Rab5a as the responsible factor mediating the listericidal action of interferon-gamma

Text-mined interactions from Literome

Xaus et al., J Immunol 1999 : The stimulation of A2B receptors by adenosine or its analogues inhibits the IFN-gamma induced expression of MHC class II genes and also the IFN-gamma induced expression of nitric oxide synthase and of proinflammatory cytokines
Díaz-Guerra et al., J Immunol 1999 : Negative regulation by protein tyrosine phosphatase of IFN-gamma dependent expression of inducible nitric oxide synthase
Saura et al., J Mol Biol 1999 : We investigated the molecular mechanism for the synergistic induction of inducible nitric oxide synthase transcription by TNF-alpha and IFN-gamma ... This interaction may explain the mechanism by which IFN-gamma synergistically augments inducible nitric oxide synthase transcription
Xu et al., Biochem Pharmacol 2000 (Glioma) : Inducible nitric oxide synthase in P11 cells : expression in the presence of interferon-gamma , lipopolysaccharide, and modified serum
Yoo et al., Free Radic Biol Med 2000 : Ionizing radiation potentiates the induction of nitric oxide synthase by interferon-gamma (Ifn-gamma) or Ifn-gamma and lipopolysaccharide in bnl cl.2 murine embryonic liver cells : role of hydrogen peroxide
Tian et al., Cytokine 2000 : Osteopontin has been shown to inhibit the induction of inducible nitric oxide synthase ( iNOS, or NOS2 ) by lipopolysaccharide and interferon-gamma in the RAW264.7 mouse monocyte/macrophage line and in primary mouse proximal tubule epithelial cells
McKinney et al., Ann N Y Acad Sci 2000 : Ionizing radiation potentiates the induction of nitric oxide synthase by interferon-gamma and/or lipopolysaccharide in murine macrophage cell lines
Maggi et al., EMBO J 2000 : Furthermore, dsRNA + IFN-gamma stimulate inducible nitric oxide synthase expression, IkappaB degradation and NF-kappaB nuclear localization to similar levels in macrophages isolated from PKR ( -/- ) and PKR ( +/+ ) mice
Yamaoka et al., Arch Dermatol Res 2000 : Ultraviolet B radiation downregulates inducible nitric oxide synthase expression induced by interferon-gamma or tumor necrosis factor-alpha in murine keratinocyte Pam 212 cells
Morikawa et al., Infect Immun 2000 : The differential regulation of cNOS- and iNOS mediated NO production by IFN-gamma , TNF-alpha, and LPS is discussed
Momose et al., Biochim Biophys Acta 2000 : Phorbol ester synergistically increases interferon regulatory factor-1 and inducible nitric oxide synthase induction in interferon-gamma treated RAW 264.7 cells
Kang et al., Neurosci Lett 2001 (Encephalitis...) : Identification of protein kinase C isoforms involved in interferon-gamma induced expression of inducible nitric oxide synthase in murine BV2 microglia
Paludan et al., Eur Cytokine Netw 2001 : Interferon (IFN)-gamma and Herpes simplex virus/tumor necrosis factor-alpha synergistically induce nitric oxide synthase 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1
Sekine et al., Endocrinology 2001 : This action of GH may be sufficient to suppress the synergistic induction of inducible nitric oxide synthase by interferon-gamma and TNFalpha, thereby preventing the cytotoxicity to beta-cells
Murakami et al., Carcinogenesis 2002 (Adenocarcinoma...) : The combined lipopolysaccharide- and interferon-gamma stimulated protein expressions of inducible nitric oxide synthase and cyclooxygenase (COX)-2, together with the release of tumor necrosis factor-alpha, in RAW 264.7 mouse macrophages were also markedly diminished
Fecker et al., J Invest Dermatol 2002 (Breast Neoplasms...) : Inducible nitric oxide synthase is expressed in normal human melanocytes but not in melanoma cells in response to tumor necrosis factor-alpha, interferon-gamma , and lipopolysaccharide
Raso et al., Br J Pharmacol 2002 : Leptin potentiates IFN-gamma induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1
Levesque et al., Leukemia 2003 (Leukemia, Lymphocytic, Chronic, B-Cell...) : IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells
Hsiao et al., Biochem Pharmacol 2003 (Shock, Septic) : A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells
Wei et al., Biochem Pharmacol 2003 : Upon stimulation with 1 microg/mL lipopolysaccharide plus 100 U/mL interferon-gamma which induced the expression of inducible nitric oxide synthase , cultured astrocytes generated large amounts of NO as measured by nitrite assay and ESR technique
Chen et al., J Immunol 2003 : Inhibition of IFN-gamma mediated inducible nitric oxide synthase induction by the peroxisome proliferator activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway
Lüder et al., Int J Parasitol 2003 (Toxoplasmosis, Animal) : Inducible nitric oxide synthase transcripts induced by interferon-gamma alone or in combination with lipopolysaccharide were also dose-dependently down-regulated after infection of RAW264.7 cells with T. gondii
Cunha et al., Biochem Biophys Res Commun 1992 : Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages
Kilbourn et al., J Natl Cancer Inst 1992 (Hypotension) : Induction of nitric oxide synthase is augmented by interferon-gamma and blocked by IL-1 receptor antagonist and by inhibitors of RNA or protein synthesis
Gendron et al., J Neurochem 2003 : P2X7 nucleotide receptor activation enhances IFN gamma induced type II nitric oxide synthase activity in BV-2 microglial cells
van der Veen et al., J Neuroimmunol 2003 (Encephalomyelitis, Autoimmune, Experimental...) : Tissue expression of inducible nitric oxide synthase requires IFN-gamma production by infiltrating splenic T cells : more evidence for immunosuppression by nitric oxide
Huang et al., FEBS Lett 2003 : Our previous study has shown that lipophilic 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors of statins can inhibit interferon-gamma induced inducible nitric oxide synthase gene expression in RAW264.7 macrophages
Vega et al., J Leukoc Biol 2004 : This report focuses on the modulatory role of endogenous H ( 2 ) O ( 2 ) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma) induced inducible nitric oxide synthase ( NOS2 ) gene expression in rat peritoneal macrophages
Hwang et al., Biochem Biophys Res Commun 2004 : LY294002 inhibits interferon-gamma stimulated inducible nitric oxide synthase expression in BV2 microglial cells
Pannu et al., J Neurosci 2004 (Demyelinating Diseases...) : A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma mediated inducible nitric oxide synthase gene expression : implications for neuroinflammatory diseases
Huang et al., Mol Pharmacol 2004 : p38 Mitogen activated protein kinase mediates synergistic induction of inducible nitric-oxide synthase by lipopolysaccharide and interferon-gamma through signal transducer and activator of transcription 1 Ser727 phosphorylation in murine aortic endothelial cells
Coffey et al., Exp Lung Res 2004 (Sepsis...) : Induction of inducible nitric oxide synthase by lipopolysaccharide/interferon gamma and sepsis down-regulates 5-lipoxygenase metabolism in murine alveolar macrophages
Kim et al., Biochem Biophys Res Commun 2005 : Protein expression of inducible nitric oxide synthase and cyclooxygenase-2, and production of NO by these cells were induced by LPS or IFN-gamma
Martey et al., Biochem Pharmacol 2005 : In keratinocytes, IFN-gamma stimulates expression of inducible nitric oxide synthase ( NOS2 )
Vila-del Sol et al., J Leukoc Biol 2007 : Requirement of tumor necrosis factor alpha and nuclear factor-kappaB in the induction by IFN-gamma of inducible nitric oxide synthase in macrophages
Liby et al., Cancer Res 2007 (Adenocarcinoma...) : The mechanisms of action of CDDO-ME and CDDO-EA that are germane to these in vivo findings are the following results shown here in cell culture : ( a ) suppression of the ability of IFN-gamma to induce de novo formation of nitric oxide synthase in a macrophage-like cell line RAW264.7, ( b ) induction of heme oxygenase-1 in these RAW cells, and ( c ) suppression of phosphorylation of the transcription factor signal transducers and activators of transcription 3 as well as induction of apoptosis in human lung cancer cell lines
Skorokhod et al., Malaria journal 2007 (Malaria) : Malarial pigment haemozoin, IFN-gamma , TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno purified human monocytes
Pfaff et al., Int J Parasitol 2008 (Parasitemia...) : Impact of foetus and mother on IFN-gamma induced indoleamine 2,3-dioxygenase and inducible nitric oxide synthase expression in murine placenta following Toxoplasma gondii infection ... The tryptophan catabolising enzyme indoleamine 2,3-dioxygenase (IDO), as well as inducible nitric oxide synthase ( NOS2 ) are induced by IFN-gamma and can play extremely diverse roles in immune regulation, defence against pathogens and physiological homeostasis
Kim et al., J Biol Chem 2008 (Glioma) : C6 glioma cell insoluble matrix components enhance interferon-gamma stimulated inducible nitric-oxide synthase/nitric oxide production in BV2 microglial cells
Xu et al., Stem Cells 2009 : C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1, inducible nitric oxide synthase , and CCL5 in response to concomitant IFNgamma and TNFalpha
Yamada et al., Biochem Biophys Res Commun 1993 : Nitric oxide and nitric oxide synthase mRNA induction in mouse islet cells by interferon-gamma plus tumor necrosis factor-alpha
Koide et al., Hypertension 1994 : These findings suggest that interferon gamma directly induces the expression of the inducible nitric oxide synthase gene, whereas tumor necrosis factor-alpha and interleukin-1 beta induce it, at least in part, via the induction of intermediary protein ( s ), and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase
Paul et al., Br J Pharmacol 1995 : 8. These results suggest the involvement of protein kinase C, tyrosine kinase and poly-ADP ribosylation pathways in the regulation of the induction of nitric oxide synthase in RAW 264.7 macrophages by LPS and IFN gamma
Hattori et al., Nihon Naibunpi Gakkai Zasshi 1995 : [ The synergistic effect of interferon-gamma on the induction of nitric oxide synthase by lipopolysaccharide in vascular smooth muscle ]
Hamilton et al., J Clin Invest 1995 : The cooperative effects of IFN gamma and LPS on the expression of the inducible nitric oxide synthase gene were suppressed by oxidized LDL while the antagonistic effect of IFN gamma on LPS induced expression of the TNF receptor type II mRNA was not altered
Ringheim et al., Biochem Biophys Res Commun 1995 : Stimulation of these cells with E. coli lipopolysaccharide and interferon-gamma resulted in a significant induction of nitric oxide synthase activity with approximately 20 % of the total activity localized to the cell membrane
Unno et al., Crit Care Med 1995 : When intestinal epithelial ( Caco-2BBe ) monolayers were incubated with interferon-gamma in the presence of inhibitors of nitric oxide synthase ( NG-monomethyl-L-arginine NG-nitro-L-arginine-methyl ester, or NG-nitro-L-arginine ), both of the effects of the cytokine ( i.e., increased epithelial permeability and increased production of nitrite/nitrate ) were attenuated
Misko et al., J Neuroimmunol 1995 (Encephalomyelitis, Autoimmune, Experimental...) : Mediation of inflammation by encephalitogenic cells : interferon gamma induction of nitric oxide synthase and cyclooxygenase 2
Assreuy et al., Br J Pharmacol 1993 : 1. A murine macrophage cell line, J774, expressed nitric oxide ( NO ) synthase activity in response to interferon-gamma ( IFN-gamma, 10 u ml-1 ) plus lipopolysaccharide ( LPS, 10 ng ml-1 )
Bogdan et al., J Immunol 1993 : Traces of bacterial lipopolysaccharide suppress IFN-gamma induced nitric oxide synthase gene expression in primary mouse macrophages
Lee et al., J Neuroimmunol 1993 : Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 beta and interferon-gamma
Karupiah et al., Science 1993 (Ectromelia, Infectious) : Inhibition of viral replication by interferon-gamma induced nitric oxide synthase
Vilcek et al., Int Arch Allergy Immunol 1994 (Bacterial Infections) : Other studies have shown that the transcription factor IRF-1 is essential for the IFN-gamma mediated activation of the gene for the inducible nitric oxide synthase
Deguchi et al., J Interferon Cytokine Res 1995 : Exogenous and endogenous type I interferons inhibit interferon-gamma induced nitric oxide production and nitric oxide synthase expression in murine peritoneal macrophages
Sternberg et al., Eur J Immunol 1996 (Trypanosomiasis, African) : Nitric oxide mediated suppression of T cell responses during Trypanosoma brucei infection : soluble trypanosome products and interferon-gamma are synergistic inducers of nitric oxide synthase
Sanchez-Bueno et al., Biochem Biophys Res Commun 1996 (Fibrosarcoma) : Interferon-gamma dependent expression of inducible nitric oxide synthase , interleukin-12, and interferon-gamma inducing factor in macrophages elicited by allografted tumor cells
Asano et al., Nihon Kyobu Shikkan Gakkai Zasshi 1995 : All epithelial cells exhibited constitutive NOS activity that was calcium dependent, and inducible, lesser calcium dependent activity in the presence of interferon-gamma , interleukin-1 beta, tumor necrosis factor-alpha, and lipopolysaccharide
Komatsu et al., J Neuroimmunol 1996 (Astrocytoma...) : Interferon-gamma induced type I nitric oxide synthase activity inhibits viral replication in neurons
Eason et al., Arch Int Pharmacodyn Ther 1995 : Involvement of tyrosine kinase and protein kinase C in the induction of nitric oxide synthase by lipopolysaccharide and interferon-gamma in J774 macrophages ... These results provide strong evidence for the involvement of tyrosine kinases in the induction of nitric oxide synthase by LPS and IFN-gamma in J774 macrophages
Lu et al., J Immunol 1996 : Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma , endotoxin, and interaction with allogeneic T cells : nitric oxide production is associated with dendritic cell apoptosis
Vogl et al., Liver 1996 (Liver Cirrhosis, Experimental) : Interferon-gamma (IFN-gamma) induced the nitric oxide synthase more rapidly in macrophage cultures from cirrhotic livers than in controls
Ding et al., Mol Psychiatry 1997 : Cultures of human fetal astrocytes and microglia produce inducible nitric oxide synthase and nitric oxide in response to Interferon gamma and Interleukin 1 beta
Stewart et al., J Neurochem 1997 : Pretreatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric oxide synthase ... Furthermore, pretreatment of astrocytes with interferon-alpha/beta inhibited ( approximately 65 % ) stimulation by interferon-gamma of nitric oxide synthase activity and nitric oxide release
Nishiya et al., FEBS Lett 1997 (Glioma) : Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-gamma induced MAPK activation that is mediated by p21ras
Taylor et al., Cancer Res 1997 : Bryostatin-1 and IFN-gamma synergize for the expression of the inducible nitric oxide synthase gene and for nitric oxide production in murine macrophages
Gansauge et al., FEBS Lett 1997 : Induction of inducible nitric oxide synthase by tumor necrosis factor-alpha, interferon-gamma and interleukin-1beta inhibited cell proliferation and led to a G1 arrest
Guo et al., J Clin Invest 1997 : Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators
von Knethen et al., FASEB J 1997 : Lipopolysaccharide/interferon gamma up-regulated inducible nitric oxide synthase and caused nitric oxide generation and concomitant apoptotic cell death in RAW 264.7 macrophages
Jungi et al., Clin Exp Immunol 1997 : Antagonistic effects of IL-4 and interferon-gamma (IFN-gamma) on inducible nitric oxide synthase expression in bovine macrophages exposed to gram positive bacteria
McKinney et al., J Leukoc Biol 1998 : Ionizing radiation potentiates the induction of nitric oxide synthase by IFN-gamma and/or LPS in murine macrophage cell lines : role of TNF-alpha
Kleinert et al., Br J Pharmacol 1998 : 1. In human epithelial-like DLD-I cells, nitric oxide synthase (NOS) II expression was induced by interferon-gamma ( 100 u ml(-1) ) alone and, to a larger extent, by a cytokine mixture ( CM ) consisting of interferon-gamma, interleukin-1beta ( 50 u ml(-1) ) and tumor necrosis factor-alpha ( 10 ng ml(-1) )
Koblish et al., J Exp Med 1998 : Immune suppression by recombinant interleukin ( rIL ) -12 involves interferon gamma induction of nitric oxide synthase 2 ( iNOS ) activity : inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect
Hoffmann et al., Eur J Pharmacol 1998 : We show that G-CSF suppresses interferon-gamma/tumor necrosis factor-alpha (TNF-alpha) induced inducible nitric oxide synthase gene expression detected as inducible nitric oxide synthase cDNA ( cDNA concentration was 633 +/- 38 amol/microg total RNA following 24 h incubation with 100 U/ml interferon-gamma/500 U/ml TNF-alpha, and 440 +/- 14 amol/microg total RNA following 24 h incubation with 250 U/ml G-CSF +/- 100 U/ml interferon-gamma/500 U/ml TNF-alpha, respectively )
Frank et al., J Invest Dermatol 1998 : Coordinated induction of inducible nitric oxide synthase and GTP-cyclohydrolase I is dependent on inflammatory cytokines and interferon-gamma in HaCaT keratinocytes : implications for the model of cutaneous wound repair
Ookawauchi et al., J Hepatol 1998 : The effect of tumor necrosis factor-alpha and interferon-gamma on L-arginine transport, mRNA expression of cationic amino acid transporter and inducible nitric oxide synthase , and nitric oxide production of stellate cells was assessed ... Interferon-gamma in combination with tumor necrosis factor-alpha induced nitric oxide production with an enhancement in cationic amino acid transporter-2B mRNA expression, inducible nitric oxide synthase mRNA expression, and L-arginine transport, while extracellular L-lysine competitively inhibited this nitric oxide production ... In transformed hepatic stellate cells, tumor necrosis factor-alpha and interferon-gamma have a crucial role in nitric oxide production, and extracellular L-arginine transport and inducible nitric oxide synthase expression are regulated in a differential cytokine-specific manner