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GRAP2 — NGF
Text-mined interactions from Literome
Wooten et al., Mol Cell Biol 2000
:
Inhibitors of PKC-iota activity and PI3K had no effect on
NGF induced MAPK or
p38 activation but reduced NGF stimulated c-Jun N-terminal kinase activity
Jung et al., Mol Pharmacol 2003
:
In parallel with its increasing effect on the neurite extension and expression of neurofilament, 15-deoxy-PGJ ( 2 ) enhanced
NGF induced
p38 MAP kinase expression and its phosphorylation in addition to the activation of transcription factor AP-1 in a dose dependent manner
Jiang et al., Mol Immunol 2008
:
Furthermore, LPS induced upregulation of
NGF and p75 ( NTR ) could be
inhibited by
p38MAPK inhibitor SB203580 and NF-kappaB inhibitor PDTC, suggesting TLR4 triggered activation of p38MAPK and NF-kappaB pathways are responsible for the process
Morooka et al., J Biol Chem 1998
(Adrenal Gland Neoplasms...) :
Here we show that
NGF induces sustained activation of
p38 , a subfamily member of the MAPK superfamily, and that inhibition of the p38 pathway blocks neurite outgrowth in PC12 cells