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IL13 — MMP8
Text-mined interactions from Literome
Meisser et al., Mol Hum Reprod 1999
:
The aim of this study was to determine the
effects of tumour necrosis factor alpha (TNF),
interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of
matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Wahlgren et al., J Pathol 2001
(Bone Diseases...) :
Phorbol-12-myristate-13-acetate,
interleukin-6 , and tumour necrosis factor-alpha and heparin with the tumour promoter or cytokines potently
enhanced ( up to nine-fold )
MMP-8 and -13 expression by the RPMI 8226 myeloma cell line, as evidenced by western blotting and semi-quantitative reverse transcriptase-polymerase chain reaction
Sun et al., Connect Tissue Res 2003
(Arthritis, Rheumatoid) :
Furthermore, the
induction of the
MMP expression and activities by
interleukin-1 was suppressed by the oscillatory shear
Ma et al., J Immunol 2004
(Inflammation) :
C10/CCL6 neutralization also decreased the ability of
IL-13 to
stimulate the production of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha,
MMP-2 , MMP-9, and cathepsins-K, -L, and -S and the ability of IL-13 to inhibit alpha1-antitrypsin
Madala et al., J Immunol 2010
(Fibrosis...) :
Instead, we observed marked increases in MMP2 and MMP13 expression, suggesting that Mmp12 was promoting fibrosis by limiting the expression of specific ECM degrading MMPs. Interestingly, like MMP12,
MMP13 expression was highly
dependent on
IL-13 and type II-IL-4 receptor signaling
Saw et al., Am J Pathol 2011
(Fibrosis...) :
Differences between pemphigoid and normal conjunctival fibroblasts with respect to collagen contraction and
MMP secretion in the
presence of
interleukin-13 were also observed
Fujisawa et al., Int J Cancer 2012
(Neoplasm Invasiveness...) :
Mechanistically,
IL-13 enhanced ERK1/2, AP-1 and
MMP activities only in IL-13Ra2 positive cells but not in IL-13Ra2 negative cells