◀ Back to IL6
IL6 — PTPN11
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
Complex of GAB1-PTPN11
→
IL6
(increases)
Podar et al., J Biol Chem 2004
Evidence: IL-6-induced Association of Gab1 and Gab2 with SHP2 Is Hck-mediated.....IL-6-induced tyrosine phosphorylation of Gab1 and Gab2, as well as their association with SHP2, were markedly decreased in MM cells with kinase-inactive Hck versus MM cells with wild-type Hck. In anti-Grb2 immunoprecipitates, IL-6-induced tyrosine phosphorylation of Gab1 and Gab2, but not their association with Grb2, was abrogated (Fig. 6b). Taken together, these data further confirm that IL-6-induced Gab protein tyrosine ph...
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OpenBEL Selventa BEL large corpus:
Complex of GAB2-PTPN11
→
IL6
(increases)
Podar et al., J Biol Chem 2004
Evidence: IL-6-induced Association of Gab1 and Gab2 with SHP2 Is Hck-mediated.....IL-6-induced tyrosine phosphorylation of Gab1 and Gab2, as well as their association with SHP2, were markedly decreased in MM cells with kinase-inactive Hck versus MM cells with wild-type Hck. In anti-Grb2 immunoprecipitates, IL-6-induced tyrosine phosphorylation of Gab1 and Gab2, but not their association with Grb2, was abrogated (Fig. 6b). Taken together, these data further confirm that IL-6-induced Gab protein tyrosine ph...
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OpenBEL Selventa BEL large corpus:
Complex of PIK3R1-PTPN11
→
IL6
(increases)
Hideshima et al., Oncogene 2001*
Evidence: that IL-6 triggers activation of PI3-K and its association with SHP2, inactivates caspase-9, and protects against Dex-induced apoptosis.
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OpenBEL Selventa BEL large corpus:
Complex of PTK2B-PTPN11
→
IL6
(increases)
Chauhan et al., J Biol Chem 2000*
Evidence: We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.
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NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
SHP2 (PTPN11)
(modification, activates)
Lang et al., Nat Immunol 2003, Schaper et al., Biochem J 1998
Evidence: mutant phenotype, physical interaction, other species
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NCI Pathway Database IL6-mediated signaling events:
SHP2 (PTPN11)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK)
(modification, collaborate)
Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
Evidence: mutant phenotype, physical interaction
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NCI Pathway Database SHP2 signaling:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
SHP2 (PTPN11)
(modification, activates)
Schaper et al., Biochem J 1998
Evidence: mutant phenotype, physical interaction
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Reactome Reaction:
IL6
→
PTPN11
(indirect_complex)
Stahl et al., Science 1995*, Symes et al., Curr Biol 1997*, Schaper et al., Biochem J 1998
-
Reactome Reaction:
IL6
→
PTPN11
(reaction)
Stahl et al., Science 1995*, Symes et al., Curr Biol 1997*, Schaper et al., Biochem J 1998
Text-mined interactions from Literome
Chauhan et al., J Biol Chem 2000
(Multiple Myeloma) :
We show that
IL-6 triggers selective activation of
SHP2 and its association with RAFTK in Dex treated MM cells
Anderson et al., Semin Hematol 2001
(Multiple Myeloma) :
Apoptosis of myeloma cells triggered by corticosteroids is mediated by related focal adhesion tyrosine kinase ( RAFTK ) ; blocking RAFTK inhibits this apoptosis inducing effect
IL-6 activates
SHP2 , which inhibits RAFTK activation, thereby protecting multiple myeloma cells from the apoptotic effects of corticosteroids
Hideshima et al., Oncogene 2001
(MAP Kinase Signaling System...) :
We demonstrate that Dex induced apoptosis in MM.1S cells is mediated by downstream activation of caspase-9, with resultant caspase-3 cleavage ; and conversely, that
IL-6 triggers activation of PI3-K and its association with
SHP2 , inactivates caspase-9, and protects against Dex induced apoptosis
Sobota et al., Cell Signal 2008
:
Mouse embryonic fibroblasts expressing a SIRP1alpha protein which lacks the intracellular part show enhanced
SHP2 phosphorylation and ERK1/2 activation in
response to
IL-6 , suggesting that SIRP1alpha affects IL-6 signalling through SHP2
Wilson et al., J Virol 2008
:
Furthermore,
NS1 expression also
inhibited TLR3 dependent production of
interleukin-6 and the establishment of an antiviral state
Graf et al., Arch Biochem Biophys 2008
:
CD95L induced caspase activation leads to degradation of gp130, thereby suppressing
IL-6 induced phosphorylation of STAT3 ( Tyr ( 705 ) ) and of tyrosine phosphatase
SHP2 ( Tyr ( 580 ) )
Chen et al., J Cell Biochem 2010
(Inflammation) :
In contrast, inhibition of
SHP-2 enzymatic activity ( sodium stibogluconate ) abrogated the increased ERK phosphorylation associated with integrin beta4 silencing in LPS treated EC and
attenuated the increases in levels of
IL-6 and IL-8 in integrin-beta4 silenced EC
Moffatt et al., J Virol 1996
:
Our novel finding,
IL-6 induction by
NS1 , supports the possible relationship between parvovirus B19 infection and polyclonal activation of B cells in rheumatoid arthritis and indicates that NS1 protein may play a significant role in the pathogenesis of some B19 associated diseases by modulating the expression of host cellular genes
Berger et al., Blood 1997
(Multiple Myeloma) :
Prior treatment of U266 cells with IFN-beta downregulated
IL-6 induced tyrosine phosphorylation of gp130, Jak2,
PTP1D/Syp , Shc, and Erk2, and GTP loading of p21ras ... Further analysis indicated that treatment with IFN-beta disrupted
IL-6 induced binding of
PTP1D/Syp to gp130 and the adaptor protein Grb2 ; IFN-beta pretreatment also interfered with IL-6 induced interaction of Shc with Grb2 and a 145-kD tyrosine phosphorylated protein
Moffatt et al., J Virol 1998
:
Mutations engineered into the nucleoside triphosphate binding domain of NS1 significantly rescued cells from NS1 induced apoptosis without having any effect on
NS1 induced activation of the
IL-6 gene expression which is mediated by NF-kappaB ... Furthermore, using pentoxifylline, an inhibitor of NF-kappaB activation, we demonstrate that the NF-kappaB mediated
IL-6 activation by
NS1 is uncoupled from the apoptotic pathway
Ogata et al., Clin Cancer Res 1997
(Multiple Myeloma) :
gp130 phosphorylation, gp130-to-PTP1D binding, PTP1D phosphorylation, and
PTP1D-to-Grb2 binding are also
induced by
IL-6 in all IL-6 independent MM cell lines studied