◀ Back to IL13
IL13 — VCAM1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
VCAM1
→
IL13
(increases)
Evidence: TABLE 1. Cytokine/chemokines, their receptors, and functions.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Weigel et al., Clin Chem Lab Med 1999
:
In contrast, MPA neither induced VCAM-1 nor did it influence the
effects of IL-4 and
IL-13 on
VCAM-1 expression
Fukushi et al., J Immunol 2000
(Corneal Neovascularization) :
Both IL-4 and
IL-13 markedly
increased mRNA levels of
VCAM-1 in vascular endothelial cells, and the production of the soluble form of VCAM-1 was also stimulated in response to IL-4 or IL-13
Kawakami et al., Oncol Res 2001
(Brain Neoplasms...) :
Interestingly,
IL-13 increased the expression level of
VCAM-1 in A172 cell line in a dose- and time dependent manner
Kumagai et al., Cornea 2003
:
Synergistic
effect of TNF-alpha and either IL-4 or
IL-13 on
VCAM-1 expression by cultured human corneal fibroblasts ... To examine the role of corneal fibroblasts in the pathogenesis of vernal keratoconjunctivitis, we investigated the
effects of tumor necrosis factor (TNF)-alpha, interleukin (IL)-4, and
IL-13 on the expression of
vascular cell adhesion molecule (VCAM)-1 by cultured human corneal fibroblasts
Banning et al., Free Radic Biol Med 2004
:
Inhibition of basal and
interleukin-1 induced
VCAM-1 expression by phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase in rabbit aortic smooth muscle cells
Hosokawa et al., Clin Exp Immunol 2006
:
On the other hand, IL-4 and
IL-13 enhanced only
VCAM-1 expression on HGF
Fukuda et al., Allergol Int 2006
(Conjunctivitis, Allergic) :
Stimulation of fibroblasts in the corneal stroma with the combination of a proinflammatory cytokine and either IL-4 or
IL-13 results in up-regulation of the expression of the chemokine eotaxin and thymus- and activation regulated chemokine as well as of
vascular cell adhesion molecule-1 , which together mediate the infiltration and activation of eosinophils and Th2 cells
Sironi et al., Blood 1994
:
Induction of
VCAM-1 by
IL-13 was selective in that E-selectin and intercellular adhesion molecule-1 ( ICAM-1 ) were unaffected
Bochner et al., J Immunol 1995
:
IL-13 selectively
induces vascular cell adhesion molecule-1 expression in human endothelial cells ... These results demonstrate that IL-13, like IL-4, selectively stimulates HUVEC to express functional cell surface VCAM-1 and suggest a possible
role for
IL-13 in promoting
VCAM-1/alpha 4 integrin dependent accumulation of eosinophils during allergic and other inflammatory reactions in vivo
Deisher et al., Life Sci 1993
(Second Messenger Systems) :
Surface protein expression of
vascular cell adhesion molecule-1 , endothelial leukocyte adhesion molecule-1, or intercellular adhesion molecule-1, which is
induced by tumor necrosis factor,
interleukin-1 , and lipopolysaccharide, was not induced by pentoxyfilline, a phosphodiesterase inhibitor, nor by dibutyryl cyclic adenosine monophosphate
Kotowicz et al., Int Immunol 1996
:
In addition,
IL-13 and IL-4
stimulate comparable levels of
VCAM-1 expression with similar time kinetics, but at doses 10-fold less than those required for B cell activation and proliferation
Ying et al., J Immunol 1997
(Hypersensitivity) :
IL-13 , like IL-4,
induces up-regulation of
vascular cell adhesion molecule-1 ( VCAM-1 ) expression on human endothelial cells in vitro
Jahnsen et al., Am J Pathol 1997
(Burkitt Lymphoma...) :
IL-4 or
IL-13 combined with submaximal concentrations of IL-1 beta or tumor necrosis factor-alpha
increased VCAM-1 expression in a synergistic manner ... Taken together, our results supported the notion that selective
VCAM-1 induction by IL-4 and
IL-13 plays an important role for the preferential recruitment of eosinophils and T lymphocytes seen in human airways affected by allergy
Goebeler et al., Immunology 1997
:
In contrast to the synergistic
effect of
IL-13 and tumour necrosis factor-alpha (TNF-alpha) on endothelial vascular cell adhesion molecule-1 (
VCAM-1 ) surface expression, TNF-alpha induced secretion of MCP-1 is not augmented by IL-13
Miller et al., J Leukoc Biol 1998
:
Utilizing neutralizing antibodies, we show that CD40L mediated tissue factor and thrombomodulin modulation, as well as E-selectin and
VCAM-1 upregulation, is
independent of tumor necrosis factor alpha,
interleukin-1alpha , or interleukin-1beta production
Terada et al., Allergy 1998
:
Recent studies have revealed that
interleukin (IL)-13 , as well as IL-4,
causes de novo surface expression of
vascular cell adhesion molecule-1 ( VCAM-1 ) on endothelial cells of the umbilical vein and accelerates selective eosinophil migration ... Of particular interest is whether
IL-13 upregulates
VCAM-1 expression in human mucosal microvascular endothelial cells ( HMMECs ), to which eosinophils adhere in nasal mucosa ...
IL-13 increased
VCAM-1 expression in HMMECs, the adhesiveness of endothelial cells to eosinophils, and the transendothelial migration