Gene interactions and pathways from curated databases and text-mining

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PMEL — RELA

Text-mined interactions from Literome

Bours et al., Bull Mem Acad R Med Belg 1999 (Adenocarcinoma...) : In these cells, p100 sequesters NF-kappa B in the cytoplasm and blocks the induction of NF-kappa B-dependent genes in response to stimuli such as TNF-alpha
Dejardin et al., Immunity 2002 : IKKbeta dependent activation of canonical NF-kappaB is required for the expression but not processing of p100 and for the expression of proinflammatory molecules including VCAM-1, MIP-1beta, and MIP-2 in response to LTbetaR ligation
Legarda-Addison et al., J Immunol 2007 : Consistent with this hypothesis, ectopic expression of p100 inhibited TCR mediated NF-kappaB activity and IL-2 production in Jurkat T cells
Naumann et al., Oncogene 1993 : NF-kappa B precursor p100 inhibits nuclear translocation and DNA binding of NF-kappa B/rel-factors