Wen-Sheng et al., Oncogene 2003
(Carcinoma, Hepatocellular...) :
These results suggested that activation of ERK together with its downstream transcriptional machinery mediated p15(INK4b) and p16(INK4a) expression that led to HepG2 growth inhibition
Koyama et al., Mol Cancer Ther 2007
(MAP Kinase Signaling System) :
p15(INK4b) induction was caused by MAPK/ERK kinase inhibitor ( PD98059 ), but not by Akt inhibitor ( SH-6, Akt-III )
Chen et al., Arch Biochem Biophys 2007
(MAP Kinase Signaling System) :
Moreover, high glucose induced p15(INK4b) protein expression is dependent on ERK1/2 and oxidative stress