◀ Back to BCL10
BCL10 — IKBKB
Pathways - manually collected, often from reviews:
-
NCI Pathway Database BCR signaling pathway:
IKK complex complex (CHUK-IKBKB-IKBKG)
→
CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7)
(modification, collaborate)
-
Reactome Reaction:
BCL10
→
IKBKB
(reaction)
Wang et al., Nature 2001, Zhou et al., Nature 2004, Shinohara et al., J Exp Med 2005, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Shinohara et al., Immunol Rev 2009, Zhang et al., Chin Med Sci J 2010
-
Reactome Reaction:
BCL10
→
IKBKB
(indirect_complex)
Shinohara et al., J Exp Med 2005, Sommer et al., Immunity 2005, Shinohara et al., Immunol Rev 2009
-
WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection:
Complex of MALT1-CARD11-BCL10
→
Complex of IKBKG-IKBKB-CHUK
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
BCL10
—
IKBKB
(direct interaction, enzymatic study)
Lobry et al., Proc Natl Acad Sci U S A 2007*
-
IRef Biogrid Interaction:
BCL10
—
IKBKB
(physical association, affinity chromatography technology)
Lobry et al., Proc Natl Acad Sci U S A 2007*
-
IRef Biogrid Interaction:
BCL10
—
IKBKB
(physical association, affinity chromatography technology)
Poyet et al., J Biol Chem 2001*
-
MIPS CORUM CASP8-CHUK-IKBKB-MALT1-BCL10 complex:
CASP8-CHUK-IKBKB-MALT1-BCL10 complex complex (BCL10-CASP8-CHUK-IKBKB-MALT1)
Su et al., Science 2005
-
MIPS CORUM BCL10-CHUK-BCL10-IKBKB complex:
BCL10-CHUK-BCL10-IKBKB complex complex (BCL10-CASP8-CHUK-IKBKB)
Su et al., Science 2005
-
IRef Corum Interaction:
Complex of IKBKB-CHUK-BCL10-CASP8-MALT1
(association, coimmunoprecipitation)
Su et al., Science 2005
-
IRef Corum Interaction:
Complex of CASP8-BCL10-CHUK-IKBKB
(association, coimmunoprecipitation)
Su et al., Science 2005
-
IRef Dip Interaction:
Complex of CARD11-MALT1-IKBKB-CSNK1A1-BCL10
(anti bait coimmunoprecipitation)
Bidère et al., Nature 2009*
-
IRef Dip Interaction:
Complex of MALT1-MALT1-BCL10-BCL10-CSNK1A1-CSNK1A1-IKBKB-IKBKB
(anti bait coimmunoprecipitation)
Bidère et al., Nature 2009*
Text-mined interactions from Literome
Patke et al., Curr Opin Immunol 2004
:
BCR signaling leads to
activation of the inhibitor of NF-kappa B kinase
(IKK) complex via Carma1,
Bcl10 and MALT1, whereas BAFF-R engagement promotes processing of NF-kappa B2 protein p100, which is dependent on NF-kappa B-inducing kinase (NIK) and IKK alpha
Sun et al., Mol Cell 2004
(Lymphoma, B-Cell, Marginal Zone) :
Strikingly, only these oligomeric forms of
BCL10 and MALT1 can
activate IKK in vitro
Wegener et al., Mol Cell 2006
:
While being essential for triggering initial CBM complex formation,
IKKbeta dependent phosphorylation of
Bcl10 exhibits a negative regulatory role in T cell activation
Hinz et al., Science's STKE : signal transduction knowledge environment 2007
:
IKK triggers
Bcl10 degradation by the ubiquitin-proteasome system through phosphorylation of Bcl10 at other sites