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KLF4 — NOTCH2

Text-mined interactions from Literome

Ghaleb et al., Mol Cancer Res 2008 (Adenoma...) : Conversely, overexpression of Notch in HT29 cells reduced KLF4 levels, suppressed KLF4 promoter activity, and increased proliferation rate ... Inhibition of Notch signaling increases KLF4 expression and goblet cell differentiation and reduces proliferation and tumor formation
Zheng et al., Am J Physiol Gastrointest Liver Physiol 2009 : The aim of this study was to examine whether Notch represses KLF4 expression to regulate goblet cell differentiation ... Our findings thus reveal a possible mechanism by which KLF4 is inhibited by Notch , which controls goblet cell differentiation in mouse gastrointestinal tract