Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Cui et al., Biochem Cell Biol 2004 (Breast Neoplasms) : This effect of IFN-gamma was observed in concentration- and time dependent manners, and IFN-gamma also induced promoter activity of RIG-I ... Overexpression of RIG-I induced the upregulation of IFN-gamma stimulated gene 15, which has the potential to amplify the immunomodulatory effects ... We conclude that IFN-gamma induces the expression of RIG-I , which may play a role in the immunological effects of IFN-gamma
Imaizumi et al., Endothelium : journal of endothelial cell research 2004 : In the present study, the authors found that IFN-gamma also induces the expression of RIG-I in human umbilical vein endothelial cells ... Although the physiological function of RIG-I is still unknown, induction of RIG-I by IFN-gamma may play an important role in inflammatory or immunological reactions in endothelial cells
Kitamura et al., J Dermatol Sci 2007 (Psoriasis) : The present study was designed to investigate the effects of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha on RIG-I expression in human keratinocytes, and the expression of RIG-I in skin lesions of psoriasis vulgaris, in which IFN-gamma and TNF-alpha are considered to be involved in its pathogenesis
Imaizumi et al., J Atheroscler Thromb 2007 (Atherosclerosis) : IFN-gamma slightly enhanced the RIG-I expression in THP-1 cells ... IFN-gamma also stimulated the expression of RIG-I in monocyte derived macrophages
Matsumiya et al., J Immunol 2007 (Uterine Cervical Neoplasms) : It was previously reported that IFN-gamma induces the expression of RIG-I in endothelial cells
Yuzawa et al., Life Sci 2008 : The aim of the present study was to investigate the effect of IFN-gamma on RIG-I expression in HeLa cells, a cell line derived from human uterine carcinoma
Kawaguchi et al., Immunol Lett 2009 (Colonic Neoplasms) : RIG-I was constitutively expressed in the epithelial cell lines HT-29, and IFN-gamma and TNF-alpha enhanced the RIG-I expression in a dose dependent manner