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PI3 — TRAF6
Text-mined interactions from Literome
Funakoshi-Tago et al., Eur J Biochem 2003
:
Furthermore,
TRAF6 and c-Src induced JNK activation was significantly
inhibited by
PI3-kinase inhibitor or a dominant negative mutant of Akt ( Akt DN )
Wang et al., J Cell Sci 2006
:
It was observed that
PI 3-kinase was
activated either by treatment with IL-1 or by expression of either
TRAF6 , Src, MyD88 or dominant positive PI 3-kinase, and resulted in the formation of long filopodia-like cellular protrusions that appeared to branch at membrane sites consisting of clusters of phosphoinositide ... Although a key factor in
TRAF6 dependent activation of
PI 3-kinase , ectopic expression of Src was insufficient for NF-kappaB activation and, in contrast to NF-kappaB, was not inhibited by IRAK2