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IRS1 — PPARG

Text-mined interactions from Literome

Miki et al., Mol Cell Biol 2001 : Our results suggest that IRS-1 and IRS-2 play a crucial role in the upregulation of the C/EBPalpha and PPARgamma expression and adipocyte differentiation
Iwata et al., Diabetes 2001 (Insulin Resistance) : Overexpression of the PPAR-gamma proteins in TNF-alpha treated adipocytes restored protein levels of IR/IRS-1 , but did not improve insulin stimulated tyrosine phosphorylation of IR/IRS-1 or insulin stimulated 2-DOG uptake ... These results indicate that the ability of pioglitazone to restore insulin stimulated tyrosine phosphorylation of IR/IRS-1 , which is necessary for amelioration of TNF-alpha induced insulin resistance, may be independent of the adipogenic activity of PPAR-gamma that regulates protein levels of IR/IRS-1