UCSC Genome Browser Gene Interaction Graph

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Gene interactions and pathways from curated databases and text-mining

◀ Back to IL3

IL3 — YWHAZ

Pathways - manually collected, often from reviews:

NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ/SHC complex (CSF2RB-YWHAZ-SHC1-IL3-IL3RA) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
NCI Pathway Database IL3-mediated signaling events: YWHAZ (YWHAZ) → IL3/IL3RA/CSF2RB (dodecamer) complex (CSF2RB-IL3-IL3RA) (modification, collaborate)
Guthridge et al., Mol Cell 2000, Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL3-mediated signaling events: YWHAZ (YWHAZ) → IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ complex (CSF2RB-YWHAZ-IL3-IL3RA) (modification, collaborate)
Guthridge et al., Mol Cell 2000, Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer) complex (CSF2RB-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ complex (CSF2RB-YWHAZ-IL3-IL3RA) (modification, collaborate)
Guthridge et al., Mol Cell 2000, Barry et al., J Biol Chem 2009
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ/SHC complex (CSF2RB-YWHAZ-SHC1-IL3-IL3RA) → SHC (SHC1) (modification, collaborate) Barry et al., J Biol Chem 2009, Gotoh et al., EMBO J 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ/SHC complex (CSF2RB-YWHAZ-SHC1-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ complex (CSF2RB-YWHAZ-IL3-IL3RA) (modification, collaborate)
Barry et al., J Biol Chem 2009, Gotoh et al., EMBO J 1996
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL3-mediated signaling events: SHC (SHC1) → IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ complex (CSF2RB-YWHAZ-IL3-IL3RA) (modification, collaborate)
Barry et al., J Biol Chem 2009, Gotoh et al., EMBO J 1996
Evidence: mutant phenotype, physical interaction
Reactome Reaction: YWHAZ → IL3 (indirect_complex) Stomski et al., Blood 1999
Reactome Reaction: YWHAZ → IL3 (reaction) Stomski et al., Blood 1999