Gene interactions and pathways from curated databases and text-mining

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NFKB1 — REL

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Haddad et al., J Pharmacol Exp Ther 2002 (Inflammation...) : Whereas selective inhibition of PDEs 1, 3, and 4, by the action of 8-methoxymethyl-3-isobutyl-1-methylxanthine, amrinone, and rolipram, respectively, exhibited a tendency to augment the translocation of NF-kappaB ( 1 ) ( p50 ), RelA ( p65 ), RelB ( p68 ), and c-Rel ( p75 ), selective blockade of PDE 5, 6, and 9, by the action of 4- [ [ 3',4'- ( methylenedioxy ) benzyl ] amino ] -6-methoxyquinazoline and zaprinast, attenuated lipopolysaccharide-endotoxin (LPS) mediated NF-kappaB translocation
Szabo et al., Frontiers in bioscience : a journal and virtual library 2002 : Activation of NF-kappa B , however, is regulated at multiple levels including I-kappa B degradation, nuclear translocation, and by interaction of NF-kappa B/Rel with other transcription factors
Monaco et al., Proc Natl Acad Sci U S A 2004 (Arteriosclerosis...) : We found that NF-kappa B is activated in these cells and that this activity involves p65, p50, and c-Rel but not p52 or RelB
Ravi et al., Drug Resist Updat 2004 (Neoplasms) : NF-kappaB may be inhibited by targeting either the apical signaling proteins responsible for its activation in specific types of cancer, the downstream kinases ( IkappaB kinase and casein kinase 2 ) at which NF-kappaB activating signaling pathways converge, the proteasome mediated degradation of the inhibitor of kappaB ( IkappaB ) proteins, or the transcriptional activity of Rel proteins
Iwamoto et al., Tohoku J Exp Med 2005 (Body Weight...) : Supershift assays with specific antibodies revealed that p50, but not p52, p65, Rel B, or c-Rel , may be involved in the activation of NF-kappaB , though the component primarily responsible for the increase could not be determined
Thornburg et al., Oncogene 2006 (Lymphoma) : The LMP1 mediated activation of NF-kappaB may contribute to the specific activation of c-Rel and lead to the increased development of lymphoma in the LMP1 transgenic mice
Ballard et al., Cell 1990 : v-Rel , but not nontransforming v-Rel mutants, binds to the kappa B enhancer and inhibits NF-kappa B-activated transcription from the IL-2 receptor alpha promoter and HIV-1 LTR