◀ Back to NFKB1
NFKB1 — REL
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of NFKB1-RELA-RELB-REL-NFKB2
Nonaka et al., Oncogene 2005
-
IRef Bind Interaction:
Complex of 25 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 13 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 16 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 11 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 11 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of 21 proteins
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
Complex of RELB-REL-TNIP2-NFKB1-RELA-NFKBIA-NFKB2-IKBKG-NFKB1
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Bind Interaction:
NFKB1
—
REL
Nonaka et al., Oncogene 2005
-
IRef Biogrid Interaction:
NFKB1
—
REL
(colocalization, imaging technique)
Barré et al., EMBO J 2007
-
IRef Biogrid Interaction:
NFKB1
—
REL
(physical association, affinity chromatography technology)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Biogrid Interaction:
NFKB1
—
REL
(physical association, affinity chromatography technology)
Barré et al., EMBO J 2007
-
MIPS CORUM NFKB1-NFKB2-REL-RELA-RELB complex:
NFKB1-NFKB2-REL-RELA-RELB complex complex (NFKB1-NFKB2-REL-RELA-RELB)
Nonaka et al., Oncogene 2005
-
MIPS CORUM TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2):
TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) complex (CHUK-IKBKG-KPNA3-NFKB1-NFKB2-NFKBIA-NFKBIB-NFKBIE-REL-RELA-RELB-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex:
CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex complex (CHUK-COPB2-IKBKG-NFKB1-NFKB2-NFKBIA-NFKBIE-REL-RELA-SPAG9-TNIP1-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I):
TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) complex (CHUK-DDX3X-GLG1-GTF2I-IKBKG-MAP3K8-NFKB1-NFKB2-NFKBIA-NFKBIB-REL-RELA-RELB-RPL30-RPL6-RPS13-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM TNF-alpha/NF-kappa B signaling complex 5:
TNF-alpha/NF-kappa B signaling complex 5 complex (CD3EAP-CHUK-CUL1-FBXW11-IKBKB-IKBKG-IQGAP2-KPNA2-LRPPRC-MCC-MTIF2-NFKB1-NFKB2-NFKBIB-PDCD2-POLR1A-POLR1B-POLR1D-POLR1E-POLR2H-POLR2L-RASAL2-REL-RELA-SKP1)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of NFKB1-RELB-NFKB2-REL-RELA
(association, electrophoretic mobility shift assay)
Nonaka et al., Oncogene 2005
-
IRef Corum Interaction:
Complex of 26 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 18 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 13 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 13 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Dip Interaction:
NFKB1
—
REL
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of RELA-REL-NFKB1-RELA-REL-RELA-NFKB1-NFKB1-REL
(in vivo)
Hansen et al., Mol Cell Biol 1994*
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Scheinman et al., Mol Cell Biol 1993*
-
IRef Hprd Interaction:
Complex of 290 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 145 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 145 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 626 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
NFKB1
—
REL
(in vitro)
O'Connor et al., Mol Cell Biol 2004*, Barré et al., EMBO J 2007
-
IRef Hprd Interaction:
NFKB1
—
REL
(in vivo)
O'Connor et al., Mol Cell Biol 2004*, Barré et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of COMMD1-RELA-NFKB2-NFKB1-REL-RELB
(association, pull down)
Burstein et al., J Biol Chem 2005
-
IRef Intact Interaction:
Complex of RELB-NFKB1-NFKB2-REL-SIN3A-RELA-BCL3
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Intact Interaction:
NFKB1
—
REL
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Intact Interaction:
Complex of BCL3-NFKB1-NFKB2-REL-SIN3A-RELA-NFKB2-RELB
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of REL-NFKB1-NFKB2-BCL3-SIN3A-NFKB2
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Ophid Interaction:
NFKB1
—
REL
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
NFKB1
—
REL
(aggregation, confirmational text mining)
Bouwmeester et al., Nat Cell Biol 2004
Text-mined interactions from Literome
Haddad et al., J Pharmacol Exp Ther 2002
(Inflammation...) :
Whereas selective inhibition of PDEs 1, 3, and 4, by the action of 8-methoxymethyl-3-isobutyl-1-methylxanthine, amrinone, and rolipram, respectively, exhibited a tendency to augment the translocation of NF-kappaB ( 1 ) ( p50 ), RelA ( p65 ), RelB ( p68 ), and
c-Rel ( p75 ), selective blockade of PDE 5, 6, and 9, by the action of 4- [ [ 3',4'- ( methylenedioxy ) benzyl ] amino ] -6-methoxyquinazoline and zaprinast,
attenuated lipopolysaccharide-endotoxin (LPS) mediated
NF-kappaB translocation
Szabo et al., Frontiers in bioscience : a journal and virtual library 2002
:
Activation of
NF-kappa B , however, is
regulated at multiple levels including I-kappa B degradation, nuclear translocation, and by interaction of NF-kappa
B/Rel with other transcription factors
Monaco et al., Proc Natl Acad Sci U S A 2004
(Arteriosclerosis...) :
We found that
NF-kappa B is activated in these cells and that this activity
involves p65, p50, and
c-Rel but not p52 or RelB
Ravi et al., Drug Resist Updat 2004
(Neoplasms) :
NF-kappaB may be
inhibited by targeting either the apical signaling proteins responsible for its activation in specific types of cancer, the downstream kinases ( IkappaB kinase and casein kinase 2 ) at which NF-kappaB activating signaling pathways converge, the proteasome mediated degradation of the inhibitor of kappaB ( IkappaB ) proteins, or the transcriptional activity of
Rel proteins
Iwamoto et al., Tohoku J Exp Med 2005
(Body Weight...) :
Supershift assays with specific antibodies revealed that p50, but not p52, p65, Rel B, or
c-Rel , may be
involved in the activation of
NF-kappaB , though the component primarily responsible for the increase could not be determined
Thornburg et al., Oncogene 2006
(Lymphoma) :
The LMP1 mediated activation of
NF-kappaB may
contribute to the specific activation of
c-Rel and lead to the increased development of lymphoma in the LMP1 transgenic mice
Ballard et al., Cell 1990
:
v-Rel , but not nontransforming v-Rel mutants, binds to the kappa B enhancer and
inhibits NF-kappa B-activated transcription from the IL-2 receptor alpha promoter and HIV-1 LTR