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JAK2 — MYC
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Xie et al., Oncogene 2002
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Jak2 is
involved in
c-Myc induction by Bcr-Abl ... Since the Jak2 binds to the C-terminal domain of Bcr-Abl and optimal Jak2 activation requires the SH2 domain, we tested whether
Jak2 was
involved in
c-Myc protein induction by Bcr-Abl ... In summary, our findings indicate that
Jak2 mediates the increase in
c-Myc expression that is induced by Bcr-Abl ... Our results indicate that activated
Jak2 not only
mediates an increase of
c-MYC RNA expression but also interferes with proteasome dependent degradation of c-Myc protein
Samanta et al., Cancer Res 2006
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Similar to wild-type Bcr-Abl+ cells, inhibition of
Jak2 by Ag490 treatment
resulted in decrease of pSer Akt and
c-Myc in imatinib-resistant cells
Konforte et al., J Immunol 2006
:
Our study is the first to show the link between IL-21 induced
JAK/STAT signaling,
c-Myc regulation , and differentiation of human B cells
Lee et al., J Cell Biochem 2009
:
JAK pathway
induction of
c-Myc critical to IL-5 stimulation of cell proliferation and inhibition of apoptosis ... We further examined the
role of JAK1 and
JAK2 in the induction of
c-Myc expression using the CDJAK fusion proteins, which consisted of a CD16 extracellular domain, a CD7 transmembrane domain, and either JAK1 ( CDJAK1 ) or JAK2 ( CDJAK2 ) as intracellular domains ... Simultaneous activation of JAK1 and
JAK2 by anti-CD16 antibody crosslinking of CDJAK1 and CDJAK2 could
induced c-Myc expression and promoter activity ; AG490 inhibited CDJAK1 and CDJAK2 mediated effects
Li et al., PloS one 2012
(Hypereosinophilic Syndrome) :
Interestingly,
JAK2 inhibition also reduced PI3K, Akt and NF-?B activity in a dose dependent manner, and
suppressed expression levels of
c-Myc and Survivin ... Interestingly,
JAK2 inhibition also reduced PI3K, Akt and NF-?B activity in a dose dependent manner, and
suppressed expression levels of
c-Myc and Survivin