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ARG1 — NOX1
Text-mined interactions from Literome
Morris et al., Br J Haematol 2000
(Acute Disease...) :
L-Arg ( 0.1 g/kg )
increased NOx formation by 18.8 +/- 68 % in normal controls, whereas steady-state SCD patients demonstrated a paradoxical decrease in NOx of -16.7 +/- 4 % ( P = 0.004 )
Zhan et al., J Histochem Cytochem 2003
:
L-Arg ( 100 microM )
increased NOx levels significantly ( p < 0.05 ) ... In explants exposed to inhibitors of NOS, the
effect of
l-Arg on the production of
NOx was blocked
Zhang et al., Am J Pathol 2009
(Disease Models, Animal...) :
In conclusion, these studies suggest that LPS induced retinal inflammation in endotoxin induced uveitis is mediated by
NADPH oxidase dependent increases in
arginase activity
Caldwell et al., Brain Res Bull 2010
(Retinal Neovascularization) :
Furthermore, the induction of
arginase during retinopathy is
blocked by knocking out NOX2 or inhibiting
NADPH oxidase activity
Shin et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011
:
In HUVECs, inhibition of
arginase activity by CLE reciprocally
increased NOx production through enhancement of eNOS dimer stability without any significant changes in the protein levels of eNOS and arginase II expression
Yabuki et al., Brain Res 2013
(Disease Models, Animal...) :
In addition, we devised a novel protocol to analyze NOx ( - ) ( NO ( 2- ) and NO ( 3- ) ) productions following L-Arg infusion using in vivo microdialysis and revealed that decreased
L-Arg induced
NOx ( - ) levels were improved in the hippocampus of BCCAO mice following repeated L-Cit administration
Verhoeven et al., J Biol Chem 1993
:
In electropermeabilized neutrophils, the myristoylated pseudosubstrate
Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln ( myr-psi PKC )
inhibited PMA induced protein phosphorylations and activation of the
NADPH oxidase , induced either by PMA or by the receptor agonist formyl-methionyl-leucyl-phenylalanine