McGettrick et al., Eur J Biochem 2001
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The reactive centre loop sequence is essential for this function and TNF induced cathepsin G is a candidate target
Mezyk-Kopeć et al., Biol Chem 2005
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Effects of elastase and cathepsin G on the levels of membrane and soluble TNFalpha Owen et al., J Immunol 1995
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In this study, we describe expression of neutrophil cell surface bound cathepsin G in response to TNF-alpha and platelet activating factor (PAF) under conditions in which minimal free release of cathepsin G is detected ... TNF-alpha and PAF alone induced modest ( two- to threefold ) increases in cell surface bound cathepsin G , but exhibited a marked dose- and time dependent priming effect for subsequent chemoattractant induced responses ( up to 15- to 25-fold increases in cell surface expression )