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NGF — PGD

Text-mined interactions from Literome

Toyomoto et al., FEBS Lett 2004 : We found that prostaglandin ( PG ) D ( 2 ) and PGE ( 2 ), which are major PGs in the brain of mammals, powerfully induced the secretion of nerve growth factor (NGF) from cultured mouse astrocytes ; PGE ( 2 ) or PGD ( 2 ) induced an approximately 12- or 19-fold increase in NGF secretion after a 24-h incubation, respectively
Bulló et al., Am J Physiol Endocrinol Metab 2005 : In marked contrast, prostaglandin PGD ( 2 ) induced a major, dose dependent increase ( up to 20- to 40-fold ) in NGF expression and secretion ... It is concluded that PGD ( 2 ) and the J series prostaglandins, PGJ ( 2 ) and Delta ( 12 ) -PGJ ( 2 ), can play a significant role in the regulation of NGF production by white adipocytes
Murakami et al., J Immunol 1997 : Addition of type II secretory phospholipase A2 ( sPLA2 ), a PLA2 isoform that is detected in microg/ml levels in inflammatory exudates, to NGF stimulated CTMC significantly augmented delayed, but not immediate, PGD2 generation, and this augmentative effect was mediated in part by the enhancement of COX-2 expression by sPLA2
Tada et al., J Immunol 1998 : A type IIA sPLA2 inhibitor, but neither cytosolic PLA2 nor COX inhibitors, reduced, while adding exogenous type IIA sPLA2 augmented, NGF induced COX-2 expression and its attendant PGD2 generation, indicating that the sPLA2 mediated increase in delayed PGD2 generation was attributable mainly to enhanced COX-2 expression