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MAP3K3 — MAPK3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK3 → MAP3K3 (increases, MAP3K3 Activity, MAPK3 Activity) Channavajhala et al., Biochem Biophys Res Commun 2005*
  Evidence: hKSR-2 also regulates the activity of MEKK3 (another MAP3K family member) in HEK-293T cells. We demonstrate that hKSR-2 is a negative regulator of MEKK3-mediated activation of MAP kinase (specifically ERK and JNK) and NF-kappaB pathways, and concurrently inhibits MEKK3-mediated interleukin-8 production.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: MAPK3 — MAP3K3 (phosphorylation reaction, protein kinase assay) Fritz et al., J Biol Chem 2006*

Text-mined interactions from Literome

Deacon et al., J Biol Chem 1999 : We have examined the regulation by MEKK3 of MAPK kinase 7 ( MKK7 ) and MKK6, two novel MAPK kinases specific for JNK and p38, respectively
Korchnak et al., Cell Signal 2009 : Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase ( MAP3K ) that activates multiple mitogen activated protein kinase ( MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Wang et al., J Immunol 2011 (MAP Kinase Signaling System) : Furthermore, the IL-12/IL-18-driven IFN-? production and MAPK activation in Mekk3-deficient T cells was not affected suggesting that MEKK3 may selectively mediate the TCR induced MAPK signals for IFN-? production
López-Pelaéz et al., Mol Biol Cell 2012 (Inflammation...) : Cot/tpl2 is the only MAP3K that activates MKK1/2-Erk1/2 in Toll-like receptor activated macrophages