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ADCY10 — SRGN

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Bushfield et al., Eur J Biochem 1990 : Hepatocytes from obese Zucker rats displayed a resistance to both agonist induced phosphorylation of alpha Gi-2 and to p [ NH ] ppG mediated inhibition of adenylate cyclase ... Incubation of hepatocytes from lean animals with ligands which lead to the phosphorylation of alpha Gi-2 abolished the ability of low concentrations of p [ NH ] ppG to inhibit adenylate cyclase expressed in isolated membranes
Pyne et al., FEBS Lett 1989 : This was accompanied by the loss of inhibitory effect of Gi on adenylate cyclase, as judged by the inability of low concentrations of p [ NH ] ppG to inhibit forskolin stimulated adenylate cyclase activity
Pyne et al., Biochem Biophys Res Commun 1989 : The ability of p [ NH ] ppG to inhibit forskolin stimulated adenylate cyclase activity was attenuated in the presence of insulin
Terman et al., Biochem J 1985 : p [ NH ] ppG stimulated adenylate cyclase activity was reconstituted by mixing samples from the gel-filtration column containing Gs with C unit
Houslay et al., Biochem J 1980 : 3. Trypsin treatment of intact hepatocytes has no effect on the basal, fluoride-, GTP- or p [ NH ] ppG stimulated adenylate cyclase activity
Levi et al., Int J Androl 1982 (Leydig Cell Tumor...) : In contrast, the GTP analogue p ( NH ) ppG ( guanosine 5'beta, gamma-imido triphosphate ) caused a persistent activation of the adenylate cyclase
Heyworth et al., Biochem J 1983 : The lag observed in the p [ NH ] ppG stimulated adenylate cyclase activity of native membranes was abolished when membranes from glucagon pretreated cells were used
Setchenska et al., Biochem J 1983 : Both GTP and p [ NH ] ppG increased the adenylate cyclase activity of early and late erythroblasts, whereas the stimulating effect of the beta-adrenergic drug L-isoprenaline was limited to the immature dividing bone-marrow cells
Dix et al., Biochem J 1982 (Leydig Cell Tumor) : However, after mixing lutropin desensitized Leydig tumour-cell plasma membranes with freshly prepared human erythrocyte plasma membranes, the adenylate cyclase activity in the presence of lutropin, p [ NH ] ppG , lutropin plus p [ NH ] ppG and NaF were similar to those of control cell plasma membranes treated in the same manner
Levi et al., Int J Androl 1982 (Leydig Cell Tumor...) : In contrast p ( NH ) ppG ( 10 ( -5 ) M ) and p ( NH ) ppG plus LH increased adenylate cyclase activity 7 and 14-fold which was maintained for at least 45 min. Fluoride ions increased the enzyme activity linearly over 45 min approx 18-fold
Spence et al., Biochem J 1993 : At 35 degrees C, the addition of benzyl alcohol led to the apparent abolition of the lag period for p [ NH ] ppG activation of adenylate cyclase and amplified the steady-state rate by only around 2.2-fold