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DUSP6 — MAPK12

Pathways - manually collected, often from reviews:

• KEGG MAPK signaling pathway: DUSP1/DUSP10/DUSP14/DUSP16/DUSP2/DUSP22/DUSP3/DUSP4/DUSP5/DUSP6/DUSP7/DUSP8/DUSP9 → MAPK11/MAPK12/MAPK13/MAPK14 (protein-protein, inhibition)
  

Text-mined interactions from Literome

Reffas et al., Biochem J 2000 : Activation of mitogen activated protein kinases ( MAPKs ), their upstream activators MAPK kinases ( MAPKKs or MEKs ) and induction of MKP-1 ( CL100/3CH134 ) and MKP-3 ( Pyst1/rVH6 ) dual-specificity MAPK phosphatases ( MKPs ) were studied in the mouse embryonic stem cell line P19 during the 7 day induction of neuronal differentiation triggered by aggregation and retinoic acid
Givant-Horwitz et al., Gynecol Oncol 2004 (MAP Kinase Signaling System...) : The objective of the present study was to investigate the expression and clinical role of dual-specificity phosphatases ( DUSP ) , inhibitors of MAPK signaling, in ovarian cancer cells at this site
Cui et al., Cancer Res 2006 (Breast Neoplasms) : Furthermore, PD98059 increased the levels of phosphorylated c-Jun NH ( 2 ) -terminal kinase ( JNK ) in tamoxifen treated MKP3 overexpressing cells, suggesting an interaction between MKP3 levels, activation of ERK1/2 MAPK , and JNK signaling in human breast cancer cells
Kumabe et al., Microbiol Immunol 2010 : Activation of MAPK is negatively regulated by DUSP , which dephosphorylate the phosphothreonine and phosphotyrosine residues
Camps et al., Science 1998 : Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen activated protein kinase