Zhang et al., Inflamm Res 2003
:
uPAR up-regulated the Mac-1 adhesion to fibrinogen and FAK and MAPK were involved in this regulation
Saldanha et al., J Proteome Res 2007
(Ovarian Neoplasms) :
Inhibition of uPAR and/or beta6 integrin subunit using neutralizing antibodies resulted in the inhibition of uPA mediated ERK 1/2 phosphorylation and subsequent cell proliferation
Liu et al., PloS one 2011
(Inflammation) :
However, uPAR is required for optimal p38 MAPK activation after TLR2 engagement
Tang et al., J Biol Chem 1998
:
Thus, this study demonstrates a novel role for the uPAR in endothelial cell signal transduction that involves the activation of FAK and MAPK , which are mediated by the receptor binding domain of uPA