◀ Back to WNT1
RYK — WNT1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Wnt signaling network:
WNT1/FZD8/Ryk complex (WNT1-FZD8-RYK)
→
WNT1 (WNT1)
(modification, collaborate)
Lu et al., Cell 2004*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Wnt signaling network:
WNT1/FZD8/Ryk complex (WNT1-FZD8-RYK)
→
Ryk (RYK)
(modification, collaborate)
Lu et al., Cell 2004*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Wnt signaling network:
WNT1/FZD8/Ryk complex (WNT1-FZD8-RYK)
→
FZD8 (FZD8)
(modification, collaborate)
Lu et al., Cell 2004*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Wnt signaling network:
WNT1 (WNT1)
→
Ryk (RYK)
(modification, collaborate)
Lu et al., Cell 2004*
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
WNT1
→
RYK
(direct_complex)
Lu et al., Cell 2004*, Liu et al., Nat Neurosci 2005*, Schmitt et al., Nature 2006*, Keeble et al., J Neurosci 2006*, Keeble et al., Int J Biochem Cell Biol 2006*, Lyu et al., Dev Cell 2008*, Fradkin et al., Trends Neurosci 2010*, Berndt et al., J Cell Biol 2011, Macheda et al., J Biol Chem 2012*
-
Reactome Reaction:
WNT1
→
RYK
(reaction)
Lu et al., Cell 2004*, Liu et al., Nat Neurosci 2005*, Schmitt et al., Nature 2006*, Keeble et al., J Neurosci 2006*, Keeble et al., Int J Biochem Cell Biol 2006*, Lyu et al., Dev Cell 2008*, Fradkin et al., Trends Neurosci 2010*, Berndt et al., J Cell Biol 2011, Macheda et al., J Biol Chem 2012*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Harris et al., Development 2007
:
Different
Wnt signals
act through the Frizzled and
RYK receptors during Drosophila salivary gland migration
Sternberg et al., WormBook : the online review of C. elegans biology 2005
:
The reversed polarity of the posterior secondary precursor cell lineage requires
WNT signaling
mediated by both Frizzled class and
Ryk class WNT-receptors LIN-17 and LIN-18, respectively
Zhong et al., Dev Cell 2008
:
Their findings point to the possibility that
Ryk , an atypical receptor tyrosine kinase, directly
regulates Wnt target gene expression
Macheda et al., J Biol Chem 2012
(Wnt Signaling Pathway) :
Overall, our data suggest an important
role for
Ryk in
Wnt/planar cell polarity signaling during vertebrate development via the Vangl2 signaling pathway, as demonstrated in the mouse cochlea