◀ Back to TLR2
TIRAP — TLR2
Pathways - manually collected, often from reviews:
-
KEGG Toll-like receptor signaling pathway:
TLR2
→
Complex of MYD88-TIRAP-TOLLIP
(protein-protein, activation)
-
KEGG Toll-like receptor signaling pathway:
TLR2
→
Complex of MYD88-TIRAP-TOLLIP
(protein-protein, activation)
-
NCI Pathway Database Endogenous TLR signaling:
BGN/TLR2/TLR1/MD2 (dimer)/MYD88/TIRAP complex (TLR2-TLR1-LY96-BGN-MYD88-TIRAP)
→
MYD88/TIRAP complex (MYD88-TIRAP)
(modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
BGN/TLR2/TLR1/MD2 (dimer)/MYD88/TIRAP complex (TLR2-TLR1-LY96-BGN-MYD88-TIRAP)
→
BGN/TLR2/TLR1/MD2 (dimer) complex (TLR2-TLR1-LY96-BGN)
(modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
MYD88/TIRAP complex (MYD88-TIRAP)
→
BGN/TLR2/TLR1/MD2 (dimer) complex (TLR2-TLR1-LY96-BGN)
(modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
→
MYD88/TIRAP complex (MYD88-TIRAP)
(modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
MYD88/TIRAP complex (MYD88-TIRAP)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
-
Reactome Reaction:
TIRAP
→
TLR2
(indirect_complex)
Yamamoto et al., Nature 2002, Horng et al., Nature 2002, Jefferies et al., J Biol Chem 2003, Brunner et al., Histol Histopathol 2005, Gray et al., J Biol Chem 2006, Núñez Miguel et al., PloS one 2007*, Piao et al., J Biol Chem 2008, Verstak et al., J Biol Chem 2009*, Lee et al., Proc Natl Acad Sci U S A 2012
-
Reactome Reaction:
TIRAP
→
TLR2
(reaction)
Li et al., Proc Natl Acad Sci U S A 2002, Yamamoto et al., Nature 2002, Horng et al., Nature 2002, Jefferies et al., J Biol Chem 2003, Kollewe et al., J Biol Chem 2004, Gray et al., J Biol Chem 2006, Cheng et al., Biochem Biophys Res Commun 2007, Kawagoe et al., J Exp Med 2007, Núñez Miguel et al., PloS one 2007*, Piao et al., J Biol Chem 2008, Kawagoe et al., Nat Immunol 2008, Verstak et al., J Biol Chem 2009*
-
WikiPathways Toll-like Receptor Signaling:
TLR1/TLR2
→
Complex of TOLLIP-TIRAP-MYD88
(activation)
-
WikiPathways Toll-like Receptor Signaling:
TLR2/TLR6
→
Complex of TOLLIP-TIRAP-MYD88
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhang et al., Infect Immun 2005
(Pseudomonas Infections) :
We also determined that MyD88, IRAK, TRAF6, and Toll interacting protein (Tollip), but not
TIRAP , were involved in the
TLR mediated response to P. aeruginosa in HAECs
Sacre et al., Am J Pathol 2007
(Arthritis, Rheumatoid...) :
Because
TLR2 and TLR4
require both MyD88 and
Mal/TIRAP for signaling, this study suggests that TLR function may regulate the expression of these factors in the RA synovium
Verstak et al., J Biol Chem 2009
(Bacterial Infections...) :
MyD88 adapter-like
(Mal)/TIRAP interaction with TRAF6 is
critical for
TLR2- and TLR4 mediated NF-kappaB proinflammatory responses
Cole et al., J Leukoc Biol 2010
(Inflammation) :
The
requirement for
TIRAP in
TLR2 signaling could also be overcome by increasing the concentrations of synthetic bacterial TLR2 agonists
Ghose et al., Drug Metab Dispos 2011
:
Thus, the effect of
TLR2 on DME genes in hepatocytes was
mediated by
TIRAP , whereas TIRAP was not involved in mediating the effects of TLR2 on cytokine expression in the liver
Weller et al., Blood 2012
:
TLR4 and the
TLR2 heterodimers ( with TLR1, TLR6, and possibly TLR10 )
require in addition the adaptor
TIRAP , whereas UNC-93B is needed for the proper localization of intracellular TLR3, TLR7, TLR8, and TLR9