Gene interactions and pathways from curated databases and text-mining

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TIRAP — TLR2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zhang et al., Infect Immun 2005 (Pseudomonas Infections) : We also determined that MyD88, IRAK, TRAF6, and Toll interacting protein (Tollip), but not TIRAP , were involved in the TLR mediated response to P. aeruginosa in HAECs
Sacre et al., Am J Pathol 2007 (Arthritis, Rheumatoid...) : Because TLR2 and TLR4 require both MyD88 and Mal/TIRAP for signaling, this study suggests that TLR function may regulate the expression of these factors in the RA synovium
Verstak et al., J Biol Chem 2009 (Bacterial Infections...) : MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4 mediated NF-kappaB proinflammatory responses
Cole et al., J Leukoc Biol 2010 (Inflammation) : The requirement for TIRAP in TLR2 signaling could also be overcome by increasing the concentrations of synthetic bacterial TLR2 agonists
Ghose et al., Drug Metab Dispos 2011 : Thus, the effect of TLR2 on DME genes in hepatocytes was mediated by TIRAP , whereas TIRAP was not involved in mediating the effects of TLR2 on cytokine expression in the liver
Weller et al., Blood 2012 : TLR4 and the TLR2 heterodimers ( with TLR1, TLR6, and possibly TLR10 ) require in addition the adaptor TIRAP , whereas UNC-93B is needed for the proper localization of intracellular TLR3, TLR7, TLR8, and TLR9