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AKT1 — TLR4

Text-mined interactions from Literome

Li et al., Infect Immun 2003 : Further, these studies suggest that PI3-kinase is an important mediator of LPS and IL-1 beta signaling leading to NF-kappa B activation in endothelial cells and that Akt is necessary but not sufficient for NF-kappa B activation by TLR4
Miller et al., Arterioscler Thromb Vasc Biol 2005 (Atherosclerosis) : In turn, TLR4 regulated phosphorylation of ERK1/2 but not of Akt , suggesting that mmLDL induced PI3K activation is TLR4 independent
Lentschat et al., J Immunol 2005 : In addition to inhibition of TLR4 mediated MAPK phosphorylation in macrophages, mastoparan blunted IL-1R associated kinase-1 kinase activity induced by LPS, but not by TLR2 agonists, yet failed to affect phosphorylation of Akt by phosphoinositol-3-kinase induced by either TLR2- or TLR4 mediated signaling
Ha et al., Cardiovasc Res 2005 (Cardiomegaly...) : Our results demonstrate that TLR4 is a novel receptor contributing to the development of cardiac hypertrophy in vivo and that both the TLR4 mediated pathway and PI3K/Akt/mTOR signaling are involved in the development of cardiac hypertrophy in vivo
Zhang et al., J Neuroimmunol 2008 (Disease Models, Animal) : Here, we demonstrate an essential role for the TLR4 mediated phosphoinositide 3-kinase (PI3K)/Akt signaling ... Therefore, stress modulates the immune system through TLR4 mediated PI3K/Akt signaling
Santos-Sierra et al., EMBO J 2009 : In contrast to TLR2/6, TLR2/1 does not require Mal or MyD88 for Akt phosphorylation
Doan et al., Anticancer Res 2009 (Colorectal Neoplasms) : Toll-like receptor 4 activation increases Akt phosphorylation in colon cancer cells
Fan et al., EMBO J 2010 : While FoxO1 potentiates Tlr4 signalling, activation of the latter induces AKT and subsequently inactivates FoxO1, establishing a self limiting mechanism of inflammation
Kim et al., Am J Chin Med 2010 (Inflammation...) : We examined the effect of hirsutenoxime on the Toll-like receptor 4-mediated activation of Akt and nuclear factor ( NF ) -?B in lipopolysaccharide stimulated keratinocytes ... Hirsutenoxime, a cell signaling Akt inhibitor, and Bay 11-7085, an inhibitor of NF-?B activation, attenuated the lipopolysaccharide induced expression of Toll-like receptor 4 , activation of NF-?B and Akt , and the production of chemokines and reactive oxygen/nitrogen species
Hsu et al., Cancer Res 2011 (Colorectal Neoplasms...) : Taken together, the results indicate that stimulation of the TLR4/MD2 complex by LPS activates PI3K/AKT signaling and promotes downstream ß1 integrin function, thereby increasing the adhesiveness and metastatic capacity of CRC cells
Yang et al., Mol Biol Rep 2012 (Coronary Restenosis...) : High mobility group box-1 induces migration of vascular smooth muscle cells via TLR4 dependent PI3K/Akt pathway activation
Bauerfeld et al., J Immunol 2012 : TLR4 mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages
Xia et al., J Pineal Res 2012 (Inflammation) : In addition, melatonin inhibited TLR4 mediated Akt phosphorylation in LPS stimulated macrophages
Zhang et al., Cell Biol Toxicol 2012 (Prostatic Neoplasms) : TLR4 ligation resulted in a marked increase in the phosphorylation of phosphatidylinositol 3-kinase (PI3-K) and Akt