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MMP1 — PDGFB

Text-mined interactions from Literome

Endo et al., Arch Dermatol Res 2003 (Fibrosis...) : Overexpression of p38beta2, but not of p38alpha, significantly decreased PDGF-BB induced MMP-1 promoter activity, although PDGF-BB activated signaling pathways to both p38alpha and p38beta2 ... Taken together, the results of this study indicate that p38beta2 can function as a negative regulator of MMP-1 induced by PDGF-BB in vitro, suggesting that activation of p38beta2 might contribute to the pathogenesis of cutaneous fibrosis
Karakiulakis et al., J Biol Chem 2007 (Anoxia) : PDGF-BB inhibited the synthesis and secretion of all hypoxia dependent MMP via Erk1/2 mitogen activated protein ( MAP ) kinase activation
Liu et al., Neurol Res 2008 (Disease Models, Animal...) : So, PDGF-B may induce the expression of MMP for the degradation of collagen type III on the wall of the saccular aneurysms
Wang et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2011 (Hepatitis B, Chronic) : ( 2 ) Hepatic fibrosis markers : Serum levels of PDGF-BB , TGF-1P3, and TIMP-1 significantly decreased, and serum MMP-1 level markedly increased in the treated group more than before treatment ( all P < 0.05 ). No significant difference was shown between before and after treatment in each index of the control group ( P > 0.05 )
Singer et al., Eur J Biochem 1999 : Three categories of gene expression were identified : ( a ) MMP-13, -15 and -16 mRNAs were not detected despite stimulation by various cytokines ; ( b ) MMP-2 and -14 as well as TIMP-1, -2 and -3 mRNAs were constitutively expressed but not markedly affected by the six cytokines tested ; ( c ) mRNAs for MMP-1, -9 and -11 were selectively induced by specific cytokines : insulin-like growth factor-II, epidermal growth factor (EGF), platelet derived growth factor (PDGF)-BB and interleukin (IL)-6 stimulated MMP-11 expression ; MMP-1 was induced by EGF, PDGF-BB , tumour necrosis factor (TNF)alpha and IL-1alpha, which also exerted additive effects