◀ Back to MMP1
MMP1 — MMP3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Yokoyama et al., Aliment Pharmacol Ther 2000
(Helicobacter Infections...) :
Whereas
MMP-1 was not detected in media from fibroblasts or H. pylori culture alone,
MMP-1 was
detected in cocultures ( P < 0.01 )
Dreier et al., J Cell Sci 2001
:
Because addition of plasmin, a partial activator of pro-MMP-3 and pro-MMP-1, enhanced the activation of pro-MMP-9 and
pro-MMP-1 in cocultures but not in monocultured macrophages, and the presence of
MMP-3 inhibitor II
prevented pro-MMP-9 activation, we assumed a stepwise activation process of pro-MMP-9 that is dependent on the presence of at least MMP-3 and possibly also MMP-1
Sundstrom et al., AIDS Res Hum Retroviruses 2001
(Cardiomyopathies...) :
Low levels of constitutively expressed MMP-1 and -2 were detected in individual cultures of HMVEC-C and PBMCs. NE did not
induce MMP or TIMP expression by HMVEC-C and caused modest increases ( 3- to 4-fold ) in MMP-1 and -2 by uninfected PBMCs. Increased levels of NE-induced
MMP-1 ( 5-fold ) and MMP -2 ( 15-fold ) were detected in cocultures of HMVEC-C and uninfected PBMCs. HIV infection enhanced MMP-1 ( 46-fold ) and MMP-2 ( 48-fold ) and active MMP-7 ( 33-fold ) and MMP-9 ( 50-fold ) by PBMCs. Coculture of HIV infected PBMCs with HMVEC-C increased MMP-1 ( 110-fold ) and MMP-2 ( 307-fold ) but not active MMP-7 and -9
Suzuki et al., Exp Toxicol Pathol 2001
(Fibrosis) :
In conclusion, these findings suggest that the activity of MMPs may bealtered by
MMP-1 downregulation and
inhibition of
MMP activity by PAl-1 and TIMP-1 generated from tubular epithelial cells
Nova et al., Clin Exp Metastasis 2003
:
MMP-1 was expressed in both models but
MMP-3 required the presence of living fibroblasts
Westra et al., Ann Rheum Dis 2004
(Arthritis, Rheumatoid) :
MMP-3 production was significantly
inhibited at 1 microM RWJ 67657 and
MMP-1 production at 10 microM, while TIMP-1 production was not inhibited
Cury et al., J Periodontol 2007
(Periodontal Diseases) :
Although the higher hydrocortisone concentration upregulated
MMP-1 , -2, -7, -11, and TIMP-1 ( P < 0.05 ) expression, the lower concentration induced downregulation or diminished upregulation. The lower hydrocortisone concentration
induced a 23-fold increase in
MMP-3 gene expression, whereas the higher concentration induced less upregulation ; however, protein expression was regulated similarly by both hydrocortisone concentrations. The effect of hydrocortisone on TIMP-2 expression was not significant ( P > 0.05 )
Bogatkevich et al., Arthritis Rheum 2007
(MAP Kinase Signaling System...) :
Inhibition of MMP activity by
MMP inhibitor GM1489 and
inhibition of
MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity, but significantly restored HGF inhibited collagen and CTGF accumulation
Choi et al., J Neurochem 2008
(Nerve Degeneration...) :
Under the cell stress condition,
MMP-3 is released as actMMP-3 rather than the proform ( proMMP-3 ), and catalytically active
MMP-3 added to the medium does not
cause cell death
La et al., J Periodontol 2009
:
Grape seed extract suppresses lipopolysaccharide induced
matrix metalloproteinase ( MMP ) secretion by macrophages and
inhibits human
MMP-1 and -9 activities
Wang et al., Gynecol Oncol 2011
(Neoplasm Invasiveness...) :
Furthermore,
MMP-1 and PAR1 were both significantly
induced by LPA ( 20 µM ), and siRNA silencing of
MMP-1 and PAR1 both significantly reduced LPA 's invasion promoting effect in DOV13 cells ( p < 0.05 )
Guo et al., Invest Ophthalmol Vis Sci 2012
(Conjunctival Diseases) :
TSG-6 exerts an anti-inflammatory function by counteracting the transcription of MMP-1 and
MMP-3 and the
activation of
MMP-1
Hellevik et al., Radiation oncology (London, England) 2012
(Carcinoma, Non-Small-Cell Lung...) :
AIR promoted
MMP-3 and
inhibited MMP-1 appearance to some extent, but did not affect expression of other major MMPs
Jung et al., Int J Cancer 1997
(Prostatic Hyperplasia...) :
We analyzed blood plasma concentrations of
matrix metalloproteinase-1 and -3 ( MMP-1 ; MMP-3 ), the tissue
inhibitor of metalloproteinase-1 ( TIMP-1 ) and the complex
MMP-1/TIMP-1 , and looked for any correlation with prostate cancer stage
Mellanen et al., Oral Dis 1996
(HIV Infections...) :
MMP-1 and -8 may have been
activated by
MMP-3 and/or oxidants generated by myeloperoxidase
Coker et al., Am J Physiol 1998
(Heart Failure) :
With pacing CHF, the relative abundance for MMP-1 increased to 319 +/- 94 %,
MMP-2 increased to 194 +/- 31 %, and
MMP-3 increased to 493 +/- 159 % ( all P < 0.05 )