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JUN — PDLIM7

Text-mined interactions from Literome

Izumi et al., J Virol 1999 (Cell Transformation, Viral) : LMP1 spontaneously aggregates in the plasma membrane and enables two transformation effector sites ( TES1 and TES2 ) within the 200-amino-acid cytoplasmic carboxyl terminus to constitutively engage the tumor necrosis factor receptor (TNFR) associated factors TRAF1, TRAF2, TRAF3, and TRAF5 and the TNFR associated death domain proteins TRADD and RIP, thereby activating NF-kappaB and c-Jun N-terminal kinase (JNK)
Brennan et al., J Biol Chem 2001 : It inhibits LMP1 stimulated NFkappaB, STAT, and Jun transcriptional activity
Rothenberger et al., Cell Mol Life Sci 2002 : Moreover, Ndelta25 inhibited WT LMP1 mediated induction of the transcription factors NF-kappaB and AP-1
Wang et al., Zhonghua Zhong Liu Za Zhi 2002 (Nasopharyngeal Neoplasms) : In the meantime, efforts were made to demonstrate if LMP1 regulates NF-kappa B or AP-1 activation using reporter gene analysis
Yoshizaki et al., Histol Histopathol 2002 (Carcinoma...) : LMP-1 down-regulates expression of E-cadherin, induces matrix metalloproteinase-9 and urokinase type-plasminogen activator through activation of NF-kappaB and AP-1 , and enhances cell motility via ets-1 activation
Ren et al., Laryngoscope 2004 (Carcinoma...) : LMP1 induces IL-8 mainly through the activation of NF-kappa B and partly through AP-1 in NPC model cell lines, NPC-KT, and this suggests that LMP1 plays an important role in the angiogenesis of NPC
Everly et al., J Virol 2004 (Cell Transformation, Viral) : Latent membrane protein 1 (LMP1) , the Epstein-Barr virus oncoprotein, activates NF-kappaB, phosphatidylinositol 3-kinase, mitogen activated protein kinase, and c-Jun N-terminal kinase signaling
Kondo et al., Int J Cancer 2005 (Carcinoma, Squamous Cell...) : LMP1 transfected cells with 2G/2G genotype expressed MMP1, which was abolished by activator protein-1 (AP1) dominant negative ( DN ) and Ets-DN. LMP1 also induced active MMP3, which can cleave latent MMP1, and AP1-DN and Ets-DN suppressed the MMP3 expression
Song et al., Sci China C Life Sci 2005 (Carcinoma...) : Epstein-Barr virus ( EBV ) encoded latent membrane protein 1 (LMP1) may trigger the transcription factor AP-1 including c-Jun and c-fos
Song et al., Virus Res 2005 (Carcinoma...) : In this paper, results indicated that a c-Jun/Jun B heterodimer induced by LMP1 upregulated cyclin D1 promoters activity and expression, on the contrary, downregulated p16, and maladjustment of cyclin D1 and p16 expression accelerated progression of cell cycle
Uemura et al., J Biol Chem 2006 : Epstein-Barr virus latent membrane protein 1 (LMP1) activates NF-kappaB and c-Jun N-terminal kinase (JNK) , which is essential for LMP1 oncogenic activity
Charalambous et al., Carcinogenesis 2007 (Neoplasms) : In addition, LMP1 leads to the activation of c-Jun N-terminal kinase 2 ( JNK2 ) followed by JNK1 in the effected tissue
Ikeda et al., FEBS Lett 2009 : BS69 has previously been shown to be involved in LMP1 induced c-Jun N-terminal kinase activation through CTAR2 by interacting with tumor necrosis factor (TNFR) receptor associated factor 6
Liu et al., Molecular cancer 2009 (Nasopharyngeal Neoplasms) : These results suggest that human iE kappa is active in Ig kappa expressing NPC cells and LMP1 stimulated NF-kappaB and AP-1 activation results in an augmenting activation of the iE kappa
Gewurz et al., J Virol 2011 : LMP1 ( transformation effector site 2 [ TES2 ] /C-terminal activation region 2 [ CTAR2 ] ) activates NF-?B, p38, Jun N-terminal protein kinase (JNK) , extracellular signal regulated kinase ( ERK ), and interferon regulatory factor 7 (IRF7) pathways
Shkoda et al., PLoS Biol 2012 (Cell Transformation, Viral...) : RNAi mediated knockdown proved a critical role for TNIK in canonical NF-?B and c-Jun N-terminal kinase (JNK) activation by the major EBV oncoprotein LMP1 and its cellular counterpart, the B-cell co-stimulatory receptor CD40
Li et al., BMC cancer 2013 (Cell Transformation, Viral...) : Using the small interfering RNA ( siRNA ) -H3 and histone H3 mutant ( S10A ), the effect of histone H3 Ser10 motif on LMP1 induced CNE1 cell proliferation, transformation and activator protein-1 (AP-1) activation were evaluated by CCK-8, focus forming and reporter gene assay respectively ... The knockdown and mutant ( S10A ) of histone H3 suppressed LMP1 induced CNE1 cell proliferation, foci formation and AP-1 activation
Accardi et al., PLoS Pathog 2013 : This phenomenon is mediated by the LMP-1 dependent activation of c-Jun NH2-terminal kinase 1 (JNK-1) which in turn favours the recruitment of p73 to dNp73a promoter
Tsai et al., J Virol 2013 : Furthermore, EBV latent membrane protein 1 (LMP1) mediated Jun N-terminal protein kinase activation was responsible for upregulation of CCL3 and CCL4
Sjöblom et al., J Virol 1998 : In contrast, the ATF-2/c-Jun heterodimer had only a minor stimulatory effect in the absence of EBNA2 but induced a strong transactivation of the LMP1 promoter when coexpressed with this protein