◀ Back to SERPINE1
ITGAV — SERPINE1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
LRP1 (LRP1)
→
uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3)
(translocation, activates)
Czekay et al., J Cell Biol 2003
Evidence: mutant phenotype
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
alphav/beta3 Integrin complex (ITGAV-ITGB3)
→
uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3)
(translocation, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: mutant phenotype
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
alphav/beta3 Integrin complex (ITGAV-ITGB3)
→
uPA/PAI-1 complex (SERPINE1-PLAU)
(translocation, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: mutant phenotype
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3)
→
uPA/PAI-1 complex (SERPINE1-PLAU)
(translocation, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: mutant phenotype
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3)
→
uPAR (PLAUR)
(translocation, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: mutant phenotype
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
LRP1 (LRP1)
→
uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5)
(translocation, activates)
Czekay et al., J Cell Biol 2003
Evidence: assay, physical interaction
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
alphav/beta5 Integrin complex (ITGAV-ITGB5)
→
uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5)
(translocation, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: assay, physical interaction
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
alphav/beta5 Integrin complex (ITGAV-ITGB5)
→
uPA/PAI-1 complex (SERPINE1-PLAU)
(translocation, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: assay, physical interaction
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5)
→
uPA/PAI-1 complex (SERPINE1-PLAU)
(translocation, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: assay, physical interaction
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5)
→
uPAR (PLAUR)
(translocation, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: assay, physical interaction
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3)
→
PAI-1 (SERPINE1)
(modification, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: physical interaction
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
uPA/uPAR/alphav/beta3 Integrin/Vitronectin complex (PLAUR-VTN-PLAU-ITGAV-ITGB3)
→
uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3)
(modification, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: physical interaction
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
PAI-1 (SERPINE1)
→
uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3)
(modification, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: physical interaction
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
uPA/uPAR/alphav/beta3 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB3)
→
Vitronectin (VTN)
(modification, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: physical interaction
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
PAI-1 (SERPINE1)
→
uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5)
(modification, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: physical interaction
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
uPA/uPAR/alphav/beta5 Integrin/Vitronectin complex (PLAUR-VTN-PLAU)
→
uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5)
(modification, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: physical interaction
-
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling:
uPA/uPAR/alphav/beta5 Integrin/PAI-1 complex (PLAUR-SERPINE1-PLAU-ITGAV-ITGB5)
→
Vitronectin (VTN)
(modification, collaborate)
Czekay et al., J Cell Biol 2003
Evidence: physical interaction
Text-mined interactions from Literome
Vial et al., J Cell Sci 2008
(Osteosarcoma...) :
Antagonists of the alphavbeta5 integrin mimicked the effect of PAI1 on cell morphology and fibronectin matrix deposition, indicating that stimulation of matrix assembly by
PAI1 required disruption of the interaction between the
alphavbeta5 integrin and vitronectin
Pedroja et al., J Biol Chem 2009
:
These data suggest that
PAI-1 mediated regulation of
alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease