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EPHB2 — SLC22A3

Text-mined interactions from Literome

Lan et al., Carcinogenesis 2004 : Although Raf/MEK/ERK signaling causes EMT , the mechanisms, including the signaling pathways, are as yet unclear
Xie et al., Neoplasia (New York, N.Y.) 2004 (MAP Kinase Signaling System) : However, the role of Erk in the induction of TGF-beta1 mediated EMT remains unclear
Rhyu et al., J Am Soc Nephrol 2005 (Fibrosis...) : Chemical inhibition of ERK but not p38 MAPK inhibited TGF-beta1 induced Smad 2 phosphorylation, and both MAPK inhibitors inhibited TGF-beta1- and H ( 2 ) O ( 2 ) -induced EMT
Chen et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Dominant negative MEK1, MEK2, and ERK2 block PPARgamma induced EMT , whereas constitutively active MEK1 and MEK2 induce a mesenchymal phenotype similar to that evoked by PPARgamma
Zhang et al., J Am Soc Nephrol 2007 (Disease Models, Animal...) : These findings support important profibrotic roles for plasmin that include PAR-1 dependent ERK signaling and EMT induction
Pollack et al., American journal of physiology. Renal physiology 2007 (MAP Kinase Signaling System) : Oncostatin M-induced effects on EMT in human proximal tubular cells : differential role of ERK signaling
Choi et al., Drug News Perspect 2008 (Disease Progression...) : Recent studies indicate that the EMT induced by TMPRSS4 involves activation of extracellular signal regulated kinase ( ERK ) 1/2 and mitogen activated protein kinase ( MAPK )
Zuo et al., Mol Biol Cell 2009 : Activation of ERK or p38 is required for both TGF-beta induced EMT and cell migration, whereas PI3K/Akt is necessary only for TGF-beta promoted cell migration but not for EMT
Ardura et al., J Am Soc Nephrol 2010 (Disease Models, Animal...) : Moreover, inhibition of ERK1/2 blocked EMT induced by either PTHrP ( 1-36 ), TGF-beta1, EGF, or VEGF
Shin et al., Mol Cell 2010 : Further, ERK2 but not ERK1 overexpression is sufficient to induce EMT ... Remarkably, ERK2 signaling to DEF motif containing targets is required to induce EMT and correlates with increased migration, invasion, and survival ... Importantly, the late-response gene product Fra1 is necessary for Ras- and ERK2 induced EMT through upregulation of ZEB1/2 proteins
Barnett et al., Biochem Biophys Res Commun 2011 (Prostatic Neoplasms) : In conclusion, this study shows for the first time that Snail transcription factor can regulate oxidative stress enzymes and increase ROS mediated EMT regulated in part by ERK activation
Zhou et al., Zhongguo Fei Ai Za Zhi 2013 : In NSCLC cells, ENO1 overexpression can inhibit EMT in vitro by suppressing ERK1/2 phosphorylation