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EPHB2 — POLDIP2

Text-mined interactions from Literome

Kurose et al., Nihon Yakurigaku Zasshi 1999 (Myocardial Reperfusion Injury) : In contrast with H2O2 induced activation of ERK, the activation of ERK induced by phorbol ester PMA and the activation of JNK and p38 induced by H2O2 were not affected by expression of GRK2-ct, indicating that the activation of ERK but not JNK and p38 is dependent on beta gamma subunit
Arbabi et al., J Surg Res 2001 (Carcinoma...) : Hyperosmolarity induced both p38 and ERK activation within 30 min ; however, only p38 inhibition attenuated osmotic induced COX-2 expression ; inhibition of ERK activation had no effect
Nagano et al., Int Immunol 2002 : Taken together, these results suggest that both ERK and p38 ( MAPK ) pathways are involved in LPS induced COX-2 expression and PGE ( 2 ) production in neutrophils, and IL-10 and IL-4 inhibit neutrophil prostanoid synthesis by down regulating the activation of p38 ( MAPK )
Cui et al., Chem Phys Lipids 2004 : Furthermore, we found that PD98059, an ERK pathway inhibitor, and SB203580, a p38 MAPK inhibitor , diminished AAPH induced COX-2 expression and PGE ( 2 ) production, whereas JNK inhibitor did not suppress COX-2 expression or PGE ( 2 ) production by AAPH
Yamaguchi et al., J Clin Invest 2004 (MAP Kinase Signaling System) : The expression level and activation of MEK1/2 or ERK showed no difference, but the kinase activity of apoptosis signal regulating kinase 1 ( ASK1 ), JNK, or p38 increased significantly compared with that in controls
Park et al., J Invest Dermatol 2004 (MAP Kinase Signaling System) : The heat shock induced MMP-1 and MMP-3 expression was suppressed by the inhibition of ERK and JNK but not by p38 MAPK inhibition
Shih et al., Food Chem Toxicol 2005 (Adenocarcinoma...) : In addition, the malvidin treatment significantly increased the p38 kinase expression and inhibited the ERK activity, and the effects of malvidin on caspase-3 activation were blocked, respectively, by the ERK and p38 inhibitors
Huang et al., Acta Med Okayama 2005 (Fibrosarcoma) : TNFalpha induced p38 and ERK activation, whereas oridonin triggered only ERK activation
Kandere-Grzybowska et al., Br J Pharmacol 2006 : We also investigated the effect of the flavonol quercetin that was recently shown to strongly inhibit IL-6 secretion in response to allergic stimulation from hCBMCs.IL-1 stimulated p38 , but did not activate extracellular signal regulated kinase ( ERK ) or c-jun N-terminal kinase ( JNK ) ; it also did not activate protein kinase C ( PKC ) isozymes alpha, beta, mu and zeta, except for PKC-theta, which was phosphorylated
Lee et al., Oncol Rep 2008 (MAP Kinase Signaling System...) : The ERK1/2 inhibitor, U0126 and the p38 MAP kinase inhibitor , SB203580, significantly down-regulated TNF-alpha induced MMP-9 expression and promoter activity
Choi et al., Mol Pharmacol 2010 (Breast Neoplasms) : Collectively, capsaicin induced autophagy is regulated by p38 and ERK ; p38 controls autophagy at the sequestration step, whereas ERK controls autophagy at the maturation step, and that autophagy is involved in the retardation of cell death by blocking capsaicin induced ER stress mediated apoptosis in MCF-7 and MDA-MB-321 cells
Wang et al., Oncol Rep 2010 (Carcinoma, Hepatocellular...) : Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK, p-p38 , p-p53 and p21, elevated the level of cyclin B1/p-Cdc2 ( Tyr15 ) complex, and inhibited the expression of p-ERK
Syedain et al., J Biomech 2011 : The role of TGF-ß1 activated p38 in inhibiting phosphorylation of ERK was evaluated by treating samples with SB203580, an inhibitor of p38 activation
Larsen et al., J Biol Chem 1998 : We conclude that ERK1/2 and p38 activation is necessary but not sufficient for IL-1beta mediated beta-cell NO synthesis and that p38 is involved in signaling of NO-independent effects of IL-1beta in beta-cells
Alexandrov et al., Mol Pharmacol 1998 : We conclude that there is a previously unrecognized interaction between ERK and p38 MAPK, in which activation of p38 causes inhibition of ERK ; this may at least partly involve MAPK phosphatases that inactivate ERK
McGilvray et al., J Biol Chem 1998 : Moreover, whereas inhibition of ERK had no effect on p38 activity, p38 inhibition consistently increased MHV-3 induced ERK activity