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ITPR1 — PRKAR1B

Text-mined interactions from Literome

Tang et al., J Neurosci 2003 (Calcium Signaling) : We discovered that PKA activates and PP1alpha inhibits the activity of recombinant InsP3R1 reconstituted into planar lipid bilayers
Dyer et al., Biochem Biophys Res Commun 2003 (Ion Channel Gating) : The effects of PKA on the type I InsP(3) receptor using single channel electrophysiological studies were also investigated
Hur et al., J Cell Biol 2005 (Calcium Signaling) : The IP ( 3 ) R complex functions as a focal point to promote Ca ( 2+ ) release in two ways : ( 1 ) it facilitates PKA dependent phosphorylation of IP(3)R1 in response to BK-induced elevation of cAMP, and ( 2 ) it couples the plasmalemmal EGFR with IP(3)R1 at the Ca ( 2+ ) store located juxtaposed to the plasma membrane
Soulsby et al., Cell Calcium 2007 : Several studies have shown that PKA mediated phosphorylation of IP3R1 at serines S1588 and S1755 enhances the receptor 's ability to mobilize Ca2+
Matsumoto et al., Cell Res 2012 (Calcium Signaling) : A recent report in Nature showed that PKA dependent phosphorylation of the inositol-1,4,5-trisphosphate receptor ( InsP3R ) induces Ca mobilization, leading to increase in the phosphatase activity of calcineurin and the subsequent dephosphorylation of CRTC2, thereby resulting in the induction of gluconeogenic gene expression