Cafferata et al., Biochim Biophys Acta 2000
(Adenocarcinoma...) :
Interleukin-1beta regulates CFTR expression in human intestinal T84 cells ... In this work, we have examined the effects of interleukin-1beta (IL-1beta) on the expression of CFTR in human colonic T84 cells ... These results suggest that some PKC isoform ( s ) and at least a PTK might be involved in the CFTR up-regulation induced by IL-1beta Brouillard et al., J Biol Chem 2001
:
We have investigated the effect of the pro-inflammatory peptide interleukin 1beta (IL-1beta) on the expression of the CFTR in Calu-3 cells ... Transfection experiments using -2150 to +52 CFTR reporter gene constructs showed that the activity of the CFTR promoter is enhanced by exogenous transfected NF-kappaB and IL-1beta and that this enhancement is due, at least in part, to the -1103 to -1093 kappaB site
Cafferata et al., J Biol Chem 2001
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The stimulation of CFTR , induced by IL-1beta , was also blocked in the presence of the dominant negative mutant ... These results indicate that NF-kappaB is involved in the pathway by which IL-1beta regulates CFTR