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SETD2 — TNF
Text-mined interactions from Literome
Hellwig-Bürgel et al., Blood 1999
(Anoxia...) :
Since EPO gene expression is inhibited by the proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), while no such effect has been reported with respect to the VEGF gene, we investigated the
effects of IL-1beta and
TNF-alpha on the activation of the
HIF-1 DNA binding complex and the amount of HIF-1alpha protein in human hepatoma cells in culture
Hehlgans et al., J Interferon Cytokine Res 2001
(Anoxia) :
Hypoxic upregulation of
TNF receptor type 2 expression involves NF-IL-6 and is
independent of
HIF-1 or HIF-2
Jelkmann et al., Adv Exp Med Biol 2001
(Anemia) :
HIF-1 DNA binding is also
increased by insulin, and by interleukin-1 and
tumor necrosis factor
Yu et al., J Mol Cell Cardiol 2012
:
In this study, we investigated direct effects of hypoxia on TNF-a expression of cardiomyocytes, the
role of
hypoxia inducible factor-1a (HIF-1a) in
TNF-a regulation and potential secretory pathway of TNF-a ... Results of this study indicate that under hypoxia,
HIF-1a initiates expression of
TNF-a , mediated by exosomes in cardiomyocytes