Gene interactions and pathways from curated databases and text-mining

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SETD2 — TNF

Text-mined interactions from Literome

Hellwig-Bürgel et al., Blood 1999 (Anoxia...) : Since EPO gene expression is inhibited by the proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), while no such effect has been reported with respect to the VEGF gene, we investigated the effects of IL-1beta and TNF-alpha on the activation of the HIF-1 DNA binding complex and the amount of HIF-1alpha protein in human hepatoma cells in culture
Hehlgans et al., J Interferon Cytokine Res 2001 (Anoxia) : Hypoxic upregulation of TNF receptor type 2 expression involves NF-IL-6 and is independent of HIF-1 or HIF-2
Jelkmann et al., Adv Exp Med Biol 2001 (Anemia) : HIF-1 DNA binding is also increased by insulin, and by interleukin-1 and tumor necrosis factor
Yu et al., J Mol Cell Cardiol 2012 : In this study, we investigated direct effects of hypoxia on TNF-a expression of cardiomyocytes, the role of hypoxia inducible factor-1a (HIF-1a) in TNF-a regulation and potential secretory pathway of TNF-a ... Results of this study indicate that under hypoxia, HIF-1a initiates expression of TNF-a , mediated by exosomes in cardiomyocytes