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IARS — TNF

Text-mined interactions from Literome

Poggi et al., Blood 2005 (Hemoglobinuria, Paroxysmal) : Moreover, the ligation of IRS induces ( 1 ) production of tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) and ( 2 ) brisk cytolytic activity against cells bearing appropriate IRS counter-ligands
Pawar et al., J Am Soc Nephrol 2007 (Lupus Nephritis...) : IRS 661 and IRS 954 both significantly reduced the weight of spleen and lymph nodes as well as serum levels of TNF as compared with saline treated MRL lpr mice
Cervantes et al., Proc Natl Acad Sci U S A 2011 : Using inhibitory immunoregulatory DNA sequences ( IRSs ) specific to TLR7, TLR8, and TLR9, we show that the TLR8 inhibitor IRS957 significantly diminishes production of TNF-a , IL-6, and IL-10 and completely abrogates transcription of IFN-ß in Bb-stimulated monocytes
Fong et al., J Ethnopharmacol 2011 (Cardiovascular Diseases) : The molecular mechanism of the action may include the up-regulation of IRS/AKT and JNK pathways as well as the inhibition of TNF and p38 pathways
Guo et al., J Biol Chem 1996 : In murine 3T3-L1 adipocytes, IRS-1 and PI 3-kinase phosphorylation and the association of these proteins are promoted by murine TNF , which interacts with the type 1 and type 2 TNF receptors