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GCKR — TNF

Text-mined interactions from Literome

Shi et al., J Immunol 1999 : Consistent with a role for GCKR in TNF- induced SAPK activation, a kinase-inactive mutant of GCKR is a dominant negative inhibitor of TRAF2 induced SAPK activation
Shi et al., J Biol Chem 2003 : Here, we report that TNF activates GCKR and the SAPK pathway in a manner that depends upon TRAF2 and Ubc13, a member along with Uev1A of a dimeric ubiquitin conjugating enzyme complex ... TNF signaling leads to TRAF2 polyubiquitination and oligomerization and to the oligomerization, ubiquitination, and activation of GCKR , all of which are sensitive to the disruption of Ubc13 function