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CXCL12 — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Han et al., J Clin Invest 2001
:
TNF-alpha mediates
SDF-1 alpha induced NF-kappa B activation and cytotoxic effects in primary astrocytes
Nanki et al., J Immunol 2001
(Arthritis, Rheumatoid) :
On the other hand, CCL2, CCL5, and
CXCL12 were expressed on RA FLS, and their production was
regulated by
TNF-alpha , IL-1beta, and TGF-beta1
Cheng et al., J Immunol 2002
:
We found that incubation of human dermal microvascular endothelial cells with recombinant eotaxin/CCL11 suppresses
TNF-alpha induced production of the neutrophil-specific chemokine
IL-8/CXCL8
Hardaker et al., FASEB J 2004
(Inflammation...) :
In primary cultured hASM cells taken from normal donors,
CXCL10 protein expression was
induced by IFN-gamma and
TNF-alpha , cytokines reported as elevated in COPD, and a synergistic response was obtained when they were combined
Juarranz et al., Rheumatology (Oxford) 2004
(Arthritis, Rheumatoid...) :
The effects of VIP on basal or
tumour necrosis factor alpha (TNF-alpha) stimulated production of CCL2 ( MCP-1, monocyte chemotactic protein 1 ),
CXCL8 [ interleukin (IL)-8 ], IL-6 and TNF-alpha were studied by specific ELISAs ( enzyme linked immunosorbent assays )
Salvucci et al., J Leukoc Biol 2004
(Neovascularization, Pathologic) :
In vivo,
TNF-alpha and IFN-gamma
inhibit growth factor induced angiogenesis and
SDF-1 expression in endothelial cells
Hosokawa et al., Clin Exp Immunol 2005
(Periodontal Diseases) :
Our in vitro experiments elucidated that HGF constitutively produced
CXCL12 , and the levels were
enhanced by stimulation with tumour necrosis factor-alpha
(TNF-alpha) , interferon-gamma (IFN-gamma), transforming growth factor-beta ( TGF-beta ), regulated upon activation normal T cell expressed and secreted ( RANTES ) and macrophage inflammatory protein 3(alpha) ( MIP-3(alpha) )
Green et al., J Infect Dis 2006
:
Analysis of > 1500 ARE containing cellular mRNAs, by use of microarrays, revealed that
CXCL-8 and other newly identified ARE genes were
induced by
TNF- alpha in Huh7 cells and were coordinately regulated
Ohira et al., Am J Pathol 2006
(Bile Duct Neoplasms...) :
In conclusion, the interaction of
SDF-1 released from fibroblasts and CXCR4 expressed on ICC cells may be actively involved in ICC migration, and
TNF-alpha may
enhance ICC cell migration by increasing CXCR4 expression
De Plaen et al., Immunology 2006
:
In conclusion,
CXCL2 gene is expressed in enterocytes in
response to both
TNF and LPS
Kamohara et al., Int J Oncol 2007
(Inflammation...) :
Induction of interleukin-8 (
CXCL-8 ) by
tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells : Impact of CXCL-8 as an autocrine growth factor
Kaminski et al., Lab Invest 2008
:
The chemokine
SDF-1alpha mediates firm adhesion c-kit+ cells only in the
presence of
TNF-alpha stimulation via an ICAM-1- and CXCR4 dependent mechanism
Madge et al., J Immunol 2008
:
Furthermore, the homeostatic chemokine
CXCL12 was
up-regulated by LIGHT and LTalpha1beta2 but not
TNF in both HUVEC and HDMEC
Zhang et al., Arthritis Res Ther 2008
:
TNF inhibits production of
stromal cell derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood ...
TNF reduced
SDF-1 expression by ST2 cells ... Systemically elevated
TNF levels
inhibit bone marrow stromal cell production of
SDF-1 and increase the release of bone marrow OCPs to the peripheral blood
Funakoshi-Tago et al., Biochem Pharmacol 2008
:
As a result,
TNFalpha induced expression of inflammatory cytokines,
CXCL1/KC and CCL2/MCP-1, was clearly inhibited by Celecoxib
Lee et al., J Immunol 2008
:
IL-17 strongly repressed TNF-alpha stimulated expression of CXCL10, CXCL11, and CCL5, but
synergized with
TNF-alpha for induction of
CXCL8 , CXCL1, and CCL20 mRNAs
Funakoshi-Tago et al., Cytokine 2009
:
Interestingly, we observed that
TNFalpha induced expression of IL-6,
CXCL1 and granulocyte macrophage colony stimulating factor ( GM-CSF ) were significantly enhanced in TRAF6-deficient MEFs
Subileau et al., J Neuropathol Exp Neurol 2009
(Inflammation...) :
Tumor necrosis factor strongly
increased the production of CCL2, CCL5, and
CXCL8 ; interferon gamma upregulated CXCL10 exclusively
Heuvelin et al., PloS one 2009
(Colitis) :
TNFalpha induced chemokine (
CXCL8 ) secretion and alteration of NF-kappaB and AP-1 signalling pathways by Bb were studied by EMSA, confocal microscopy and western blotting
Dai et al., Zhonghua Xue Ye Xue Za Zhi 2009
:
UCB CD34+ cells mainly home into recipient mice bone marrow and spleen ; The homing efficiency in experimental group bone marrow [ ( 0.65 +/- 0.13 ) % ] was significantly higher than that in control ones [ ( 0.30 +/- 0.09 ) %, P < 0.01 ], whereas the homing efficiency in experimental group spleen was dramatically lower than that in control ones ( P < 0.01 ) ; Treatment with TNF alpha did not affect recipient serum SDF-1 alpha level ; After 18 hours co-cultured with TNF alpha, the CXCR4e expression level on UCB CD34+ cells was similar to that on fresh ones ;
TNF alpha treatment
induced significantly higher
SDF-1 alpha expression on osteoblastic and stromal cells in bone marrow, and reversed spleen SDF-1 alpha gradient that was originally favorable for CD34+ cells homing
John et al., J Immunol 2009
(Asthma) :
Furthermore, chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and RNA polymerase II to the
CXCL8 promoter of asthmatic HASM cells both in the
presence and absence of
TNF-alpha stimulation
Földes et al., PloS one 2010
:
Expression of downstream TLR signalling pathways was demonstrated in hESC, and IL-1beta,
TNFalpha and INFgamma, which bypass the TLRs,
stimulated CXCL8 release
Stich et al., Res Vet Sci 2011
:
Lipopolysaccharide was a more potent inducer of IL-1ß and
CXCL-8 than LTA or PG and LTA is a more potent inducer of CXCL-8 than PG. Based on these data, PAMPs from gram positive and negative bacteria
induce TNF , IL-1ß and CXCL-8 production in feline whole blood
Madge et al., J Biol Chem 2010
:
We show here that
TNF inhibits both basal and LIGHT induced
CXCL12 expression ... In contrast, ectopic RelB expression recapitulated the effects of
TNF on NC signaling and
inhibited basal and LIGHT induced
CXCL12 expression by HUVEC
Robins et al., Am J Respir Cell Mol Biol 2011
(Asthma...) :
In contrast to epithelial and endothelial cells,
TNF-a stimulated
CXCL8 synthesis was dependent on ERK1/ERK2 but not on p38 MAPK
Kanda et al., Endocrinology 2011
(Psoriasis) :
Visfatin enhanced
TNF-a induced
CXC chemokine ligand ( CXCL ) 8, CXCL10, and CC chemokine ligand (CCL) 20 secretion and mRNA expression in keratinocytes, although visfatin alone was ineffective
Chen et al., Cell Prolif 2011
:
TNF-a increased EPC apoptosis level, reduced VEGF-R1 and
SDF-1 mRNA expression ; tumour necrosis factor-a also reduced iNOS and eNOS in the EPCs
Chang et al., J Allergy Clin Immunol 2012
(Asthma) :
In patients with severe asthma, dexamethasone caused less suppression of CCL11 and
CXCL8 release
induced by
TNF-a
Xu et al., Pharmacol Res 2013
:
TNF-a induced
CXCL8 production by A549 cells : Involvement of the non-neuronal cholinergic system ... In A549 cells,
TNF-a increased the release of
CXCL8 and ACh and the expression of the subtype 3 MR ( M3R ) ... Furthermore,
TNF-a induced
CXCL8 secretion was ( i ) inhibited by the MR antagonist tiotropium and the M3R antagonist 4-DAMP and ( ii ) enhanced by the M1/M3R agonist pilocarpine and the cholinesterase inhibitor physostigmine ... Taken as a whole, these results suggest that ACh release by A549 cells enhances
TNF-a induced
CXCL8 secretion through activation of the M3R ... Our results suggest that the
TNF-a induced secretion of
CXCL8 in A549 cells is regulated by the release of ACh, the latter 's binding to the M3R and the downstream activation of NF-?B and the ERK1/2 and p38 MAPK signaling pathways
Xu et al., J Immunol 2013
(Psoriasis) :
Specific inhibition of miR-31 suppressed NF-?B-driven promoter luciferase activity and the basal and
TNF-a induced production of IL-1ß, CXCL1/growth related oncogene-a, CXCL5/epithelial derived neutrophil activating peptide 78, and
CXCL8/IL-8 in human primary keratinocytes
van der Voort et al., Biol Blood Marrow Transplant 2013
(Multiple Myeloma) :
Furthermore, IFN-? and
TNF-a induced BM endothelial cells to express high levels of the inflammatory chemokines and reduced or unaltered levels of
CXCL12
Kobayashi et al., Br J Pharmacol 2013
:
Corticosteroid sensitivity was determined by IC50 /EC50 of dexamethasone ( Dex ) on
TNF-a induced
CXCL8 production in U937 monocytic cell line and peripheral blood mononuclear cells ( PBMC ) from COPD patients
Son et al., Journal of inflammation (London, England) 2013
:
Finally, CCL20 and
CXCL8 responded synergistically in
response to EGF and
TNF in OVCAR-3 and SKOV-3 cells