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DST — IL2

Text-mined interactions from Literome

Margenthaler et al., Transplantation 2003 : DST followed by a CB6F1 skin graft led to a significant deletion of donor-reactive CD8+ T cells by fluorescence activated cell sorter analysis and decreased production of the inflammatory cytokines IL-2 and interferon-gamma
Goto et al., Biosci Biotechnol Biochem 2007 : Administered BPA moderately reduced interleukin (IL)-2 , 4, and interferon (IFN)-gamma secretion and increases in IgA and IgG2a production.Additionally, it was found that orally administered BPA increased antigen-specific IFN-gamma production of T cells and modified whole antigen presenting cells (APCs) to suppress antigen-specific cytokine production from T cells
Skettino et al., Blood 1988 : These T cells were IL2 receptor negative, and the addition of anti-IL2 receptor monoclonal antibody ( anti-Tac ) to T cell cultures did not abrogate this IL2 stimulated BPA production ... We conclude that rIL2 at high concentrations stimulated T cells, Leu-2 and Leu-3 cell subsets, LGL, and NK cells to produce BPA but not GM-CSF and that this stimulation may be mediated by an IL2 receptor distinct from Tac or by an epitope of the IL2 receptor not recognized by the anti-Tac antibody
Tyler et al., Transplantation 1986 : The results suggest that inhibition of IL-2 responsiveness may be a frequent consequence of DST+A , and that the inhibition is dependent on an IL-2 mediated effect distinct from proliferation