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PGF — RAF1
Text-mined interactions from Literome
Yoshida et al., Mol Cell Endocrinol 2005
:
Tiludronate attenuated the phosphorylation of both
Raf-1 and MEK1/2
induced by
PGF2alpha
Hanai et al., Horm Metab Res 2006
:
PGF2alpha stimulated phosphorylation of
Raf-1 , MEK1/2 and p44/p42 MAP kinase were suppressed by minodronate
Hakeda et al., Endocrinology 1997
:
In addition,
PGF2alpha augmented the MAPK kinase kinase activity of
Raf-1 , whereas basal activity of MAPK/extracellular signal regulated protein kinase kinase was less than that of Raf-1 and was little affected by PGF2alpha ... Genistein, a potent inhibitor of tyrosine kinases, did not block the
Raf-1 induced by
PGF2alpha , indicating a tyrosine kinase independent pathway for Raf-1 activation
Ohmichi et al., Endocrinology 1997
:
PGF2alpha stimulation also
led to an increase in phosphorylation of
raf-1 , son of sevenless ( SOS ), and Shc
Chen et al., Endocrinology 1998
:
Raf-1 and B-Raf, but not A-Raf, were
activated by
PGF2alpha ( 1 microM ) and the pharmacological PKC activator phorbol myristate acetate ( PMA, 20 nM ) ... Kinetic analysis revealed that
PGF2alpha rapidly and transiently
activated Raf-1 ... Additionally, both
PGF2alpha ( 1 microM ) and PMA ( 20 nM )
stimulated phosphorylation of
Raf-1 , MEK1, and p42mapk in 32P labeled cells