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ARF1 — RAF1
Text-mined interactions from Literome
Sreeramaneni et al., Mol Cell Biol 2005
(Cell Transformation, Neoplastic) :
Therefore,
activation of
Arf by
Ras/Raf signaling is indirectly mediated by Dmp1, explaining why Dmp1-null primary cells are highly susceptible to Ras induced transformation
Dong et al., J Biol Chem 2011
:
Interestingly, mutation of the double Trp motif and siRNA mediated depletion of ARF1 attenuate a ( 2B ) -AR mediated activation of extracellular signal regulated kinases 1/2 ( ERK1/2 ) without altering receptor intracellular trafficking, whereas expression of the constitutively active mutant
ARF1Q71L and ARNO, a GDP-GTP exchange factor of ARF1, markedly
enhances the activation of
Raf1 , MEK1, and ERK1/2