Gene interactions and pathways from curated databases and text-mining

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ARF1 — RAF1

Text-mined interactions from Literome

Sreeramaneni et al., Mol Cell Biol 2005 (Cell Transformation, Neoplastic) : Therefore, activation of Arf by Ras/Raf signaling is indirectly mediated by Dmp1, explaining why Dmp1-null primary cells are highly susceptible to Ras induced transformation
Dong et al., J Biol Chem 2011 : Interestingly, mutation of the double Trp motif and siRNA mediated depletion of ARF1 attenuate a ( 2B ) -AR mediated activation of extracellular signal regulated kinases 1/2 ( ERK1/2 ) without altering receptor intracellular trafficking, whereas expression of the constitutively active mutant ARF1Q71L and ARNO, a GDP-GTP exchange factor of ARF1, markedly enhances the activation of Raf1 , MEK1, and ERK1/2