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PCNA — WEE1
Text-mined interactions from Literome
Wroble et al., BMC developmental biology 2007
:
One key event that occurs at the MBT is the degradation of maternal
Wee1 , a negative
regulator of
cyclin dependent kinase (Cdk) activity
Li et al., Mol Cell Biol 2010
:
RXL1 and T239 mutants each mediated greater Cdk phosphorylation and G ( 2 ) /M inhibition than the wild type, suggesting that
cyclin A/Cdk complexes
inhibit human
Wee1 through these sites
Masuda et al., Mol Biol Cell 2011
:
During the G2/M transition when cyclin B-Cdc2 is highly enriched at the SPB,
Wee1 temporally accumulates at the nuclear face of the SPB in a cyclin B-Cdc2 dependent manner and locally
suppresses both
cyclin B-Cdc2 activity and spindle assembly to counteract a Polo kinase dependent positive feedback loop
Walter et al., Mol Biol Cell 1997
:
Early MAP kinase activation did not interfere significantly with DNA replication, cyclin synthesis, or association of cyclins with Cdc2, but it did prevent hyperphosphorylation of Cdc25 and
Wee1 and
activation of
Cdc2/cyclin complexes