◀ Back to HDAC3

HDAC3 — SRC

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — HDAC3 (direct interaction, enzymatic study) Longworth et al., Oncogene 2006*
• IRef Biogrid Interaction: SRC — HDAC3 (physical association, affinity chromatography technology) Longworth et al., Oncogene 2006*
• IRef Biogrid Interaction: SRC — HDAC3 (physical association, affinity chromatography technology) Matteucci et al., Mol Cancer Res 2007*

Text-mined interactions from Literome

Kostyniuk et al., Oncogene 2002 : Sodium butyrate and Trichostatin A strongly inhibited activity of each of these highly disparate SRC promoters, demonstrating histone deacetylase inhibitors directly repress SRC transcription
Dehm et al., Biochem Cell Biol 2004 (Neoplasms) : Interestingly, histone deacetylase (HDAC) inhibitors, agents with well documented anti-cancer activity, repress SRC transcription in a wide variety of human cancer cell lines
Matteucci et al., Mol Cancer Res 2007 (Breast Neoplasms...) : Thus, the CXCR4 induction by HGF in MCF-7 cells required NF-kappaB and Ets1 activations, downstream of phosphoinositide-3-kinase/Akt, whereas in HGF treated MDA-MB231 cells, HDAC3 activation via c-Src probably caused a reduction of transcription factor activities, such as that of NF-kappaB