◀ Back to EPHB2

EPHB2 — P2RY12

Text-mined interactions from Literome

Grobben et al., J Neurochem 2001 : P2Y(AC)-receptor stimulation increased MAP kinase (ERK1/2) activation that returned to the basal level 4 h after stimulation and was correlated with a gradual desensitization of the P2Y(AC)-purinoceptor
Fälker et al., Thromb Haemost 2004 (MAP Kinase Signaling System) : ADP secretion and subsequent P2Y12 receptor signalling play a crucial role in thrombin induced ERK2 activation in human platelets
Marteau et al., J Leukoc Biol 2004 : The effect on ERK1 was inhibited by AR-C69931MX, a P2Y12 and P2Y13 antagonist
Van Kolen et al., FEBS J 2006 (Glioma...) : In this study, we show that ERK1/2 phosphorylation was not affected by transfection of the cells with the Gbetagamma-subunit scavenging adrenergic receptor kinase peptide [betaARK1- ( 495-689 ) ] or with Rap1GAPII, indicating that P2Y(12) receptor stimulation enhances ERK1/2 phosphorylation by G ( i ) alpha subunit mediated signaling independently of Rap1 activation
Mize et al., Protein Expr Purif 2008 : Notably, P2Y(12) mediated agonist induced ERK phosphorylation only when it was expressed at low levels on the cell surface, highlighting the utility of regulated expression for the production of functionally active GPCRs in mammalian cells