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EPHB2 — NTS

Text-mined interactions from Literome

Liu et al., Proc Natl Acad Sci U S A 2003 : In contrast to ERK1 and ERK2, which are activated by neurotrophins (NTs) , cAMP, and neuronal activity in cortical neurons, ERK5 is activated only by NTs
Gendron et al., Mol Pharmacol 2004 (MAP Kinase Signaling System) : NTS2 induced activation of ERK1/2 was not species-specific, because the same agonistic effects of NT and analogs were observed in CHO cells transfected with the human NTS2 receptor
Müller et al., BMC cancer 2011 (Colonic Neoplasms...) : In Panc-1 cells, neurotensin induced phosphorylation of ERK , but not Akt, was dependent on protein kinase C ( PKC ), whereas an inhibitor of the ß-isoform of phosphoinositide 3-kinase (PI3K), TGX221, abolished neurotensin induced Akt phosphorylation in these cells, and there was no evidence of EGF receptor (EGFR) transactivation ... In HT29 cells, in contrast, the EGFR tyrosine kinase inhibitor gefitinib blocked neurotensin stimulated phosphorylation of both ERK and Akt, indicating transactivation of EGFR, independently of PKC ... In HCT116 cells, neurotensin induced both a PKC dependent phosphorylation of ERK and a metalloproteinase mediated transactivation of EGFR that was associated with a gefitinib-sensitive phosphorylation of the downstream adaptor protein Shc ... In these cells, neurotensin induced activation of ERK and stimulation of DNA synthesis was PKC dependent, whereas activation of the PI3K/Akt pathway was mediated by stimulation of metalloproteinases and subsequent transactivation of the EGFR