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MKL1 — NFKB1
Text-mined interactions from Literome
Andreakos et al., Blood 2004
:
We found that MyD88 and
Mal/TIRAP are
essential for LPS induced I kappa B alpha phosphorylation,
NF-kappa B activation, and interleukin 6 (IL-6) or IL-8 production in fibroblasts and endothelial cells in a pathway that also requires IKK2 ... In contrast, in macrophages neither MyD88,
Mal/TIRAP , nor I kappa B kinase 2 (IKK2) are
required for
NF-kappa B activation or tumor necrosis factor alpha (TNF alpha), IL-6, or IL-8 production, although Mal/TIRAP is still involved in the production of interferon beta (IFN beta)
Sacre et al., J Endotoxin Res 2004
:
In cell lines and murine models, parts of the signaling pathways involved have been elucidated with MyD88,
Mal/TIRAP and IKK2 playing an important
role in the induction of
NF-kappaB ... We show that in primary human macrophages MyD88,
Mal/TIRAP and IKK2 independent alternative pathways
activate NF-kappaB and induce the expression of inflammatory cytokines, whereas in non-myeloid synovial fibroblasts MyD88 and/or Mal/TIRAP are essential adaptors for LPS signaling
Verstak et al., J Biol Chem 2009
(Bacterial Infections...) :
Furthermore,
Mal interaction with TRAF6 mediates Ser phosphorylation of the p65 subunit of NF-kappaB and thus
controls transcriptional activation but not nuclear translocation of
NF-kappaB