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LEP — NOX5
Text-mined interactions from Literome
Li et al., Diabetes 2005
:
Overall, these results demonstrate that
leptin induced HASMC proliferation and MMP-2 expression through a PKC dependent activation of
NAD ( P ) H oxidase with subsequent activation of the ERK1/2/NF-kappaB pathways and that therapeutic metformin concentrations effectively inhibit these biological effects
De Minicis et al., Hepatology 2008
(Disease Models, Animal...) :
Leptin induced
NADPH oxidase acts downstream of JAK activation but is independent of STAT3
Fortuño et al., J Hypertens 2010
(Atherosclerosis...) :
In-vitro studies showed that
leptin induced
NADPH oxidase activation ... Inhibition of the
leptin induced
NADPH oxidase activity by wortmannin and bisindolyl maleimide suggested a direct involvement of the phosphatidylinositol 3-kinase and protein kinase C pathways, respectively ... Finally,
leptin induced
NADPH oxidase activation promoted macrophage proliferation
Chatterjee et al., J Hepatol 2013
(Disease Models, Animal...) :
These results, for the first time, suggest that
leptin action in macrophages of the steatotic liver, through induction of iNOS and
NADPH oxidase ,
causes peroxynitrite mediated oxidative stress thus activating Kupffer cells