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LEP — MMP14

Text-mined interactions from Literome

Park et al., Exp Mol Med 2001 (Arteriosclerosis...) : Leptin also induced increases of MMP-2, MMP-9 , TIMP-1, and Up-regulated the human coronary artery smooth muscle cells ( HCASMCs )
Quinton et al., Am J Reprod Immunol 2003 : Expression of leptin receptor isoforms in vitro : lack of effects of leptin on endometrial cytokine and MMP production ... The effect of leptin on cell growth and on the production of cytokines [Leukaemia Inhibitory Factor (LIF), interleukin 6 and tumour necrosis factor-alpha ] and matrix metalloproteinases ( MMP ) ( MMP2 and MMP-9 ) was also investigated ... Leptin had no effect on cytokine and MMP production by these cells
Schulz et al., Biol Reprod 2004 : Our results suggest that leptin may play a role in the establishment of the placenta during early pregnancy and that this function is dependent on MMP activity
Schram et al., J Mol Cell Cardiol 2008 : Here we investigated the effects of leptin , circulating levels of which are typically increased in obese individuals, on MMP and collagen expression and MMP activity in isolated cardiac myofibroblasts ... Biotinylation assays indicated increased cell surface expression of MT1-MMP in response to leptin and use of a MT1-MMP inhibitor attenuated the leptin mediated elevation of MMP-2 activity
Bao et al., Mol Biol Rep 2010 : Leptin significantly increased both gene and protein levels of MMP-2, MMP-9 , cathepsin D, and collagen II, while decreased bFGF markedly in cartilage
Tao et al., Arterioscler Thromb Vasc Biol 2013 (Aortic Aneurysm, Abdominal...) : Leptin and leptin receptor antigen were evident in all AAAs, and leptin, MMP-9 , and MMP-12 mRNA was increased relative to age matched nondilated controls
Dong et al., Carcinogenesis 2013 (MAP Kinase Signaling System...) : Furthermore, cell surface biotinylation assay and flow cytometry demonstrated that the surface expression of MT1-MMP was also enhanced by leptin , and knockdown of kinesin family member 1B ( KIF1B, a microtubule plus end directed monomeric motor protein ) by small interference RNA inhibited this process ... Notably, coimmunoprecipitation analysis indicated that leptin enhanced the interaction of MT1-MMP with KIF1B in a time dependent manner, which consequently contributed to GC cell invasion ... Moreover, leptin increased MT1-MMP or KIF1B expression by the protein kinase B ( AKT ) pathway and extracellular signal regulated kinase 1/2 partially participated in this process ... However, only AKT was implicated in the leptin mediated membrane localization of MT1-MMP