◀ Back to LEP
CPOX — LEP
Text-mined interactions from Literome
McClelland et al., Biochim Biophys Acta 2004
(Obesity) :
Leptin ( 3 days at 0, 0.2, or 2.0 nM )
had no direct effect on the activities of CS,
COX , or fatty acid oxidizing enzymes
Luo et al., Mol Cell Biochem 2008
:
Furthermore, at the level of 10 and 100 ng/ml
leptin not only selectively increased the gene expression of PGC-1alpha, CPT1, Cyt c, UCP2, and UCP3 ( P < 0.05 ), but also
enhanced COX enzyme activity which related to mitochondrial FAO
Gao et al., Cancer Sci 2009
(Endometrial Neoplasms) :
We also showed that
leptin stimulated cell proliferation and induced activations of signal transducers and activators of transcription 3 ( STAT3 ), extracellular signal regulated kinase ( ERK1/2 ), AKT, and
cyclooxygenase (COX)-2 in endometrial cancer cells dose-dependently by [ ( 3 ) H ] thymidine incorporation assay and western blotting