Gene interactions and pathways from curated databases and text-mining

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CPOX — LEP

Text-mined interactions from Literome

McClelland et al., Biochim Biophys Acta 2004 (Obesity) : Leptin ( 3 days at 0, 0.2, or 2.0 nM ) had no direct effect on the activities of CS, COX , or fatty acid oxidizing enzymes
Luo et al., Mol Cell Biochem 2008 : Furthermore, at the level of 10 and 100 ng/ml leptin not only selectively increased the gene expression of PGC-1alpha, CPT1, Cyt c, UCP2, and UCP3 ( P < 0.05 ), but also enhanced COX enzyme activity which related to mitochondrial FAO
Gao et al., Cancer Sci 2009 (Endometrial Neoplasms) : We also showed that leptin stimulated cell proliferation and induced activations of signal transducers and activators of transcription 3 ( STAT3 ), extracellular signal regulated kinase ( ERK1/2 ), AKT, and cyclooxygenase (COX)-2 in endometrial cancer cells dose-dependently by [ ( 3 ) H ] thymidine incorporation assay and western blotting