Gene interactions and pathways from curated databases and text-mining

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GAB2 — IL2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Nishida et al., Blood 1999 : Tyrosine phosphorylation of Gab2 was induced by stimulation through gp130, IL-2R , IL-3R, TPOR, SCFR, and TCR
Gadina et al., J Biol Chem 2000 : We also demonstrate that only IL-2 and IL-15, but not other gammac cytokines induce Gab2 phosphorylation ; the ability to phosphorylate Gab2 correlates with Shc phosphorylation and ERK1/ERK2 activation
Pratt et al., J Immunol 2000 : Overexpression of Gab2 in T cell lines inhibits TCR evoked activation of the IL-2 promoter, blocking NF-AT- and NF-kappaB directed transcription
Yamasaki et al., J Biol Chem 2001 : Overexpression of Gab2 in Jurkat cells or antigen-specific T cell hybridomas resulted in the inhibition of NF-AT activation, interleukin-2 production, and tyrosine phosphorylation ... Overexpression of Gab2 in Jurkat cells or antigen-specific T cell hybridomas resulted in the inhibition of NF-AT activation, interleukin-2 production, and tyrosine phosphorylation
Arnaud et al., Biochem J 2004 (Leukemia, Prolymphocytic, T-Cell) : Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho dependent activation of the c-fos serum response element by interleukin-2